Results 31 to 40 of about 540 (144)

The Role of Dendritic Cells in Tissue‐Specific Autoimmunity

Journal of Immunology Research, Volume 2014, Issue 1, 2014., 2014
In this review, we explore the role of dendritic cell subsets in the development of tissue‐specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is becoming clear that we are only at the beginning of understanding the role of these antigen presenting cells in mediating autoimmunity.
Jacques Mbongue, Dequina Nicholas, Anthony Firek, William Langridge, Loredana Frasca   +4 more
wiley   +1 more source

Practice parameter: The role of corticosteroids in the management of acute monosymptomatic optic neuritis [RETIRED] [PDF]

Neurology, 2000
Optic neuritis (ON) is an inflammatory disorder of the optic nerve. Most cases are idiopathic or associated with MS. ON can be associated with a variety of systemic or ocular disorders and is the most common acute optic neuropathy in adults younger than 46 years.
D I, Kaufman, J D, Trobe, E R, Eggenberger, J N, Whitaker   +3 more
openaire   +2 more sources

Inflammatory Demyelinating Central Nervous System Diseases in Childhood: Clinical and Paraclinical Profiles in 133 Patients

Autoimmune Diseases, Volume 2012, Issue 1, 2012., 2012
In a retrospective review of patients with acquired demyelinating disorders of the central nervous system, 133 patients (5.6%) whose diseases started in childhood, were selected from 2369 patients, who had medical records in the Neurology Department of Dokuz Eylul University.
Derya Kaya, Egemen İdiman, Serkan Özakbaş, D. N. Bourdette   +3 more
wiley   +1 more source

Biologic Therapy in Refractory Non-Multiple Sclerosis Optic Neuritis Isolated or Associated to Immune Mediated Inflammatory Diseases. A Multicenter Study [PDF]

, 2020
We aimed to assess the e cacy of biologic therapy in refractory non-Multiple Sclerosis (MS) Optic Neuritis (ON), a condition more infrequent, chronic and severe than MS ON.
Atienza Mateo, Belén, Blanco, Ana, Blanco, Ricardo, Callejas Rubio, José Luis, Calvo Río, Vanesa, Casado, Alfonso, Castañeda, Santos, Cáceres Martín, Laura, Demetrio Pablo, Rosalía, Estrada, Paula, García Serrano, José L., González Gay, Miguel A., Hernández, José L., Herrero Morant, Alba, Maiz Alonso, Olga, Martin Varillas, José L., Martínez López, David, Narváez García, Francisco Javier, Ortego Centeno, Norberto, Prieto Peña, Diana, Romero Yuste, Susana, Rúa Figueroa, Íñigo, Sánchez, Julio, Vicente, Esther, Álvarez Reguera, Carmen   +24 more
core   +2 more sources

Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome

Behavioural Neurology, Volume 25, Issue 4, Page 311-326, 2012., 2012
The study investigates primary and secondary verbal memory and motor/executive functions (response inhibition and strategy shifting ability) in multiple sclerosis (MS) patients with clinically isolated syndrome (CIS). We studied 44 CIS patients and compared them to 49 patients with relapsing remitting MS (RR‐MS) displaying mild disability and to a ...
Theodora Panou, Vasileios Mastorodemos, Efrosyni Papadaki, Panagiotis G. Simos, Andreas Plaitakis   +4 more
wiley   +1 more source

Switching and Escalating Therapy in Long‐Lasting Multiple Sclerosis: Not Always Necessary

International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012
Although therapy switch is common among patients with multiple sclerosis (MS), sometimes the initial prescribed treatment is maintained for a long period with clinical stability, low disability, and nonsignificant side effects. We aim to describe demographic and clinical characteristics of patients treated in our MS clinic with the same disease ...
Ana Teresa Carvalho, Maria José Sá, K. Dorovini-Zis, E. A. Joosten, T. Müller, Y. Ohyagi, Y. Sunada, S. Weis   +7 more
wiley   +1 more source

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis [PDF]

, 2016
The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the trigger for induction of the KP, driving a complex cascade of production ...
Bianca Varney, Bruce J. Brew, Bruce J. Brew, Bruce J. Brew, Chai K. Lim, Gayathri Sundaram, Mei Li Ng, Michael D. Lovelace, Michael D. Lovelace, Nunzio Franco, Saparna Pai   +10 more
core   +3 more sources

The Origin of Individual Differences in the Course and Severity of Diseases

The Scientific World Journal, Volume 6, Issue 1, Page 1674-1704, 2006., 2006
Any disease manifests itself individually either by a bright or restricted spectrum of clinical signs and resultant clinical courses that range from asymptomatic to deadly, from acute to chronic, etc. Until recently, the origin of this kind of biodiversity was poorly investigated and understood, but advances in immunology — especially in identifying ...
Sergey N. Rumyantsev, Edward J. Goetzl
wiley   +1 more source

Visual outcome following optic neuritis: A 5‑year review [PDF]

, 2012
Background: Optic neuritis is a demyelinating inflammatory disease of the optic nerve that typically affects young adults especially females, and is usually associated with multiple sclerosis especially in Caucasians. The prognosis for visual recovery is
Pedro‑Egbe, CN
core   +2 more sources

Trends in optic neuritis incidence and prevalence in the UK and association with systemic and neurologic disease [PDF]

, 2020
Importance Epidemiologic data on optic neuritis (ON) incidence and associations with immune-mediated inflammatory diseases (IMIDs) are sparse.Objective To estimate 22-year trends in ON prevalence and incidence and association with IMIDs in the United ...
Adderley, Nicola, Braithwaite, Tasanee, Denniston, Alastair, Galloway, James, Mollan, Susan, Nirantharakumar, Krishnarajah, Petzold , Axel, Plant , Gordon T., Subramanian, Anuradhaa   +8 more
core   +1 more source