Results 81 to 90 of about 294 (101)
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Prognostic value of CSF IgG in monosymptomatic optic neuritis
1984The frequency with which patients with monosymptomatic optic neuritis develop multiple sclerosis (MS) is still under discussion. On the basis of clinical examinations, figures vary from 11.5 to 85%1. Various attempts have been made to study parameters which might influence the risk.
H I Schipper
exaly +2 more sources
Journal of Neurology, 2015
Optic neuritis (ON) is a common first symptom of MS and only few studies have thus far investigated vitamin D at this early stage of MS. The objectives of the study were to examine total 25-hydroxyvitamin D levels (25HVITDL) in patients in acute (A) ON and to determine whether 25HVITD levels in AON (1) predict risk of RRMS and (2) are associated with ...
Gorm Pihl-Jensen, Jette Frederiksen
exaly +3 more sources
Optic neuritis (ON) is a common first symptom of MS and only few studies have thus far investigated vitamin D at this early stage of MS. The objectives of the study were to examine total 25-hydroxyvitamin D levels (25HVITDL) in patients in acute (A) ON and to determine whether 25HVITD levels in AON (1) predict risk of RRMS and (2) are associated with ...
Gorm Pihl-Jensen, Jette Frederiksen
exaly +3 more sources
European Journal of Neurology, 1997
To evaluate various MRI criteria we studied a representative group of 149 consecutive patients below 50 years with acute monosymptomatic optic neuritis (AMON), a frequent first manifestation of multiple sclerosis (MS). The presence, number, size, and localization of areas of increased signal (AIS) on T2‐weighted brain MRIs obtained at 1.5 T were ...
J. L. Frederiksen +3 more
exaly +2 more sources
To evaluate various MRI criteria we studied a representative group of 149 consecutive patients below 50 years with acute monosymptomatic optic neuritis (AMON), a frequent first manifestation of multiple sclerosis (MS). The presence, number, size, and localization of areas of increased signal (AIS) on T2‐weighted brain MRIs obtained at 1.5 T were ...
J. L. Frederiksen +3 more
exaly +2 more sources
Multiple Sclerosis Journal, 1998
Twenty-seven patients with acute monosymptomatic optic neuritis were randomly selected from a population-based cohort of patients extensively screened for known etiologies of ON. Paired serum and CSF obtained median 20 days from onset were examined for oligoclonal IgG, free kappa and free lambda chains, and virus-specific oligoclonal IgG antibodies by ...
C J Sindic
exaly +3 more sources
Twenty-seven patients with acute monosymptomatic optic neuritis were randomly selected from a population-based cohort of patients extensively screened for known etiologies of ON. Paired serum and CSF obtained median 20 days from onset were examined for oligoclonal IgG, free kappa and free lambda chains, and virus-specific oligoclonal IgG antibodies by ...
C J Sindic
exaly +3 more sources
Multiple Sclerosis Journal, 2008
There is emerging evidence that multiple sclerosis (MS), the hypothalamic sleep-wake regulating neuropeptide hypocretin-1 (hcrt-1) and the sleep disorder narcolepsy may be connected. Thus, the major pathophysiological component of narcolepsy is lack of hcrt-1.
Poul Jennum, Stine Knudsen
exaly +4 more sources
There is emerging evidence that multiple sclerosis (MS), the hypothalamic sleep-wake regulating neuropeptide hypocretin-1 (hcrt-1) and the sleep disorder narcolepsy may be connected. Thus, the major pathophysiological component of narcolepsy is lack of hcrt-1.
Poul Jennum, Stine Knudsen
exaly +4 more sources
1999
Many patients with acute unilateral optic neuritis (ON) develop later multiple sclerosis (MS), the risk varying widely between 35% and 75% (McDonald 1983). Many MS and ON patients are subject to abnormalities of eye movements (Reulen et al 1983).
K Psilas
exaly +2 more sources
Many patients with acute unilateral optic neuritis (ON) develop later multiple sclerosis (MS), the risk varying widely between 35% and 75% (McDonald 1983). Many MS and ON patients are subject to abnormalities of eye movements (Reulen et al 1983).
K Psilas
exaly +2 more sources
Acute Monosymptomatic Optic Neuritis: Potential Clues to Early Therapy in Multiple Sclerosis
2004The optic nerve is a 50 mm by 4.5 mm white matter tract of the central nervous system (CNS). Its physiology and response to therapy can be precisely quantified by a number of common, easily available, neuro-ophthalmological techniques. Detection of an early, subtle, optic neuropathy is relatively easy compared with many of the difficult-to-document ...
exaly +2 more sources
B‐lymphocyte and plasma cell clonal expansion in monosymptomatic optic neuritis cerebrospinal fluid
Annals of Neurology, 2004AbstractThe CD19+ B‐lymphocyte and CD138+ plasma cell repertoires in cerebrospinal fluid from four patients with monosymptomatic optic neuritis (ON) were analyzed by single‐cell reverse transcriptase polymerase chain reaction. Amplified heavy (H)– and light (L)–chain antibody segments were sequenced and used to identify the rearranged germline and J ...
Kurt, Haubold +5 more
openaire +2 more sources
Multiple Sclerosis Journal, 1995
We investigated two short tandem tetranudeotide (TGGA) repeat polymorphisms upstreams of the myelin basic protein (MBP) gene. The region was amplified by the polymerase chain reaction (PCR) and the two repeat systems were separated by cutting with the restriction enzyme NlaJM.
Nellemann, L J +2 more
openaire +2 more sources
We investigated two short tandem tetranudeotide (TGGA) repeat polymorphisms upstreams of the myelin basic protein (MBP) gene. The region was amplified by the polymerase chain reaction (PCR) and the two repeat systems were separated by cutting with the restriction enzyme NlaJM.
Nellemann, L J +2 more
openaire +2 more sources