Results 61 to 70 of about 1,338,709 (361)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Multilevel Monte Carlo methods [PDF]

open access: yesActa Numerica, 2013
Monte Carlo methods are a very general and useful approach for the estimation of expectations arising from stochastic simulation. However, they can be computationally expensive, particularly when the cost of generating individual stochastic samples is very high, as in the case of stochastic PDEs.
openaire   +4 more sources

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

open access: yesFEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado   +4 more
wiley   +1 more source

Change in Cognition Following Ischaemic Stroke

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline can occur following ischaemic stroke. How cognition changes over time and associations with cognitive change are poorly understood. This study aimed to explore these issues over 2 years following ischaemic stroke.
Wenci Yan   +8 more
wiley   +1 more source

Coupled Electron Ion Monte Carlo Calculations of Dense Metallic Hydrogen

open access: yes, 2004
We present a new Monte Carlo method which couples Path Integral for finite temperature protons with Quantum Monte Carlo for ground state electrons, and we apply it to metallic hydrogen for pressures beyond molecular dissociation.
Carlo Pierleoni   +8 more
core   +2 more sources

Global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis burden, 1990–2021

open access: yesArthritis Care &Research, Accepted Article.
Objective This study examined the global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis (OA) burden from 1990 to 2021. Methods Age‐standardized years lived with disability rate for site‐specific OA across 204 countries/territories were obtained from the Global Burden of Diseases Study (GBD) 2021.
Haowei Chen   +14 more
wiley   +1 more source

Schedules of lectures and Monte Carlo method

open access: yesLietuvos Matematikos Rinkinys, 2011
In this paper the problem of the construction of schedule of lectures is considered. The Markov chain Monte Carlo method is used. A particular program based on simulated annealing algorithm was created.
Nikolaj Grigorjev   +1 more
doaj   +1 more source

Unbiased Markov chain Monte Carlo methods with couplings

open access: yesJournal of the Royal Statistical Society: Series B (Statistical Methodology), 2020
Markov chain Monte Carlo (MCMC) methods provide consistent approximations of integrals as the number of iterations goes to ∞. MCMC estimators are generally biased after any fixed number of iterations.
P. Jacob, J. O'Leary, Y. Atchadé
semanticscholar   +1 more source

Quantum Monte Carlo for minimum energy structures

open access: yes, 2010
We present an efficient method to find minimum energy structures using energy estimates from accurate quantum Monte Carlo calculations. This method involves a stochastic process formed from the stochastic energy estimates from Monte Carlo that can be ...
Jeffrey C. Grossman   +2 more
core   +1 more source

Variational Monte Carlo method for the Baeriswyl wavefunction: application to the one-dimensional bosonic Hubbard model [PDF]

open access: yes, 2016
A variational Monte Carlo method for bosonic lattice models is introduced. The method is based on the Baeriswyl projected wavefunction. The Baeriswyl wavefunction consists of a kinetic energy based projection applied to the wavefunction at infinite ...
Hetényi, B.   +2 more
core   +2 more sources

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