Results 91 to 100 of about 129,978 (318)

High‐Resolution Characterization of Protein‐Conjugated, mRNA‐Loaded Lipid Nanoparticles by Analytical Ultracentrifugation

Advanced Functional Materials, EarlyView.
Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird, Connor Smith, Nahal Habibi, Samantha Rivera, Saeed Mortezazadeh, Reece Martin, Benjamin M. Geilich, Gilles Besin, Borries Demeler   +8 more
wiley   +1 more source

Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations

Photodiagnosis and Photodynamic Therapy
Introduction: The successful diagnosis and treatment of early-stage breast cancer enhances the quality of life of patients. As a promising alternative to recently developed magnetic resonance imaging-guided radiotherapy, we proposed fluorescence ...
Yugo Minegishi, Yasutomo Nomura
doaj   +1 more source

Comparison of the atomic level structure of the plastic crystalline and the liquid phases of CBr2Cl2: neutron diffraction and Reverse Monte Carlo modeling

, 2013
Neutron diffraction results obtained for plastic crystalline dichlorodibromomethane (CBr2Cl2) have been modelled by means of the Reverse Monte Carlo method.
Cuello, Gabriel Julio, Pardo, Luis Carlos, Pothoczki, Szilvia, Rovira-Esteva, Muriel, Tamarit, Josep Lluis, Temleitner, László   +5 more
core   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

RNA structure prediction: progress and perspective

, 2014
Many recent exciting discoveries have revealed the versatility of RNAs and their importance in a variety of cellular functions which are strongly coupled to RNA structures.
Shi, Ya-Zhou, Tan, Zhi-Jie, Wang, Feng-Hua, Wu, Yuan-Yan   +3 more
core   +1 more source

Universal Electronic‐Structure Relationship Governing Intrinsic Magnetic Properties in Permanent Magnets

Advanced Functional Materials, EarlyView.
Permanent magnets derive their extraordinary strength from deep, universal electronic‐structure principles that control magnetization, anisotropy, and intrinsic performance. This work uncovers those governing rules, examines modern modeling and AI‐driven discovery methods, identifies critical bottlenecks, and reveals electronic fingerprints shared ...
Prashant Singh
wiley   +1 more source

SMILES-based QSAR and molecular docking studies of chalcone analogues as potential anti-colon cancer

Scientific Reports
QSAR modeling was applied to predict the anti-colon activity (against HT-29) of 193 chalcone derivatives using the Monte Carlo method, based on the index of ideality correlation (IIC) target function.
Abolfazl Askarzade, Shahin Ahmadi, Ali Almasirad   +2 more
doaj   +1 more source

A review on the modeling and simulations of solid-state diffusional phase transformations in metals and alloys

Manufacturing Review, 2018
Solid-state diffusional phase transformations are vital approaches for controlling of the material microstructure and thus tailoring the properties of metals and alloys.
Liu Xueyan, Li Hongwei, Zhan Mei
doaj   +1 more source

Transcriptional regulation of lineage commitment--a stochastic model of cell fate decisions.

PLoS Computational Biology, 2013
Molecular mechanisms employed by individual multipotent cells at the point of lineage commitment remain largely uncharacterized. Current paradigms span from instructive to noise-driven mechanisms.
Jose Teles, Cristina Pina, Patrik Edén, Mattias Ohlsson, Tariq Enver, Carsten Peterson   +5 more
doaj   +1 more source

Re-engineering a nanodosimetry Monte Carlo code into Geant4: software design and first results

, 2009
A set of physics models for nanodosimetry simulation is being re-engineered for use in Geant4-based simulations. This extension of Geant4 capabilities is part of a larger scale R&D project for multi-scale simulation involving adaptable, co-working ...
Gargioni, E., Grichine, V., Pia, M. G.
core   +1 more source