Results 71 to 80 of about 22,920 (247)

Montelukast, an available and safe anti-asthmatic drug, prevents maladaptive remodelling and maintains cardiac functionality following myocardial infarction

Scientific Reports
Preclinical and clinical data indicate that the 5-lipoxygenase pathway becomes activated in cardiovascular diseases suggesting an important role of CysLTs in atherosclerosis and in its ischemic complications. This study aims to investigate the effects of
Majeda Muluhie, Laura Castiglioni, Joanna Rzemieniec, Benedetta Mercuriali, Paolo Gelosa, Luigi Sironi   +5 more
doaj   +1 more source

Effect of montelukast in preventing dengue with warning signs among patients with dengue: A multicenter, randomized, double-blind, placebo-controlled trial.

PLoS Neglected Tropical Diseases
BackgroundMontelukast has shown potential as a candidate treatment for dengue. This study aimed to evaluate the efficacy and safety of montelukast in preventing dengue with warning signs.MethodsThis multicenter, randomized, double-blind, placebo ...
Nattapat Nitinai, Worapong Nasomsong, Worayon Chuerboonchai, Akarawin Tweekittikul, Vutthikorn Khingmontri, Bawornnan Panuvatvanich, Thananut Bangchuad, Maynanchaya Pongpraijaroen, Tanapol Roongfa-Ngarm, Vasin Vasikasin   +9 more
doaj   +1 more source

Montelukast Use Decreases Cardiovascular Events in Asthmatics

Frontiers in Pharmacology, 2021
Cysteinyl leukotrienes are proinflammatory mediators with a clinically established role in asthma and a human genetic and preclinical role in cardiovascular pathology.
Malvina Hoxha, Malvina Hoxha, Calogero C. Tedesco, Silvana Quaglin, Visar Malaj, Linda Pustina, Valerie Capra, Jilly F. Evans, Angelo Sala, Angelo Sala, G. Enrico Rovati   +10 more
doaj   +1 more source

A real – life observational pilot study to evaluate the effects of two-week treatment with montelukast in patients with chronic cough [PDF]

, 2014
BACKGROUND: Different conditions make the proximal airways susceptible to tussigenic stimuli in the chronic cough (CC) syndrome. Leukotrienes can be implicated in the inflammatory mechanism at play in it.
Denislava Nedeva, Karina Bacheva, Maria Staevska, Miroslava Rasheva, Penka Perenovska, Roxana K Mincheva, Tanya Z Kralimarkova, Todor A Popov, Vasil D Dimitrov, Vera Papochieva, Zlatko Dimitrov   +10 more
core   +1 more source

Resolution of Pulmonary Inflammation and Obstruction Following Repair of Cerebrospinal Fluid Leak: A Case Report and Review of the Literature

Case Reports in Pulmonology, Volume 2026, Issue 1, 2026.
Objectives Cerebrospinal fluid (CSF) rhinorrhea involves drainage of CSF through the nasal cavity due to disruption of the skull base, and pneumonitis secondary to CSF aspiration is a lesser‐known complication reported. We present the case of a patient whose pulmonary symptoms and function improved after surgical CSF leak repair. Methods This is a case
Ann O. Birmingham, Serban A. Staicu, Isaac L. Schmale, Li-Xing Man, Tun-Chieh Chen   +4 more
wiley   +1 more source

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity

Journal of Neuroinflammation, 2022
Encephalopathy of prematurity (EoP) affects approximately 30% of infants born
Abi G. Yates, Elena Kislitsyna, Carla Alfonso Martin, Jiaying Zhang, Amy L. Sewell, Ane Goikolea-Vives, Valerie Cai, Lama F. Alkhader, Aleksander Skaland, Basil Hammond, Ralica Dimitrova, Dafnis Batalle, Cathy Fernandes, A. David Edwards, Pierre Gressens, Claire Thornton, Helen B. Stolp   +16 more
doaj   +1 more source

Genetic basis for personalized medicine in asthma [PDF]

, 2012
There is heterogeneity in patient responses to current asthma medications. Significant progress has been made identifying genetic polymorphisms that influence the efficacy and potential for adverse effects to asthma drugs, including; β2-adrenergic ...
Asano, Barnes, Basu, Bleecker, Bleecker, Choudhry, Corren, Currie, Drazen, Drysdale, Duan, Duroudier, Ferreira, Finotto, Gaston, Gudbjartsson, Haldar, Hall, Hammad, Hawkins, Hawkins, Hayakawa, Himes, Holloway, Ian Sayers, Israel, Jin, Kang, Kearley, Kim, Klotsman, Koster, Lee, Lee, Lima, Lima, Litonjua, Liu, Maarsingh, Malmstrom, Mastalerz, Meurs, Michael Portelli, Moffatt, Moffatt, Moore, Mougey, Obeidat, Ober, Oshikawa, Panebra, Panebra, Pascual, Prefontaine, Reihsaus, Risma, Sampson, Savenije, Sayers, Sayers, Slager, Sleiman, Stevens, Tantisira, Tantisira, Tantisira, Tantisira, Torgerson, Trian, Tse, Vonk, Wechsler, Wenzel, Whalen, Whelan, Ye, York   +76 more
core   +2 more sources

Cost‐Effectiveness Analysis of Treatments for Children With Uncontrolled Asthma Symptoms Despite Inhaled Corticosteroids

Pediatric Pulmonology, Volume 60, Issue 12, December 2025.
ABSTRACT Introduction There is uncertainty about the cost‐effectiveness of treatment options for children and adolescents with uncontrolled asthma despite inhaled corticosteroid (ICS) treatment. Methods A Markov state‐transition model was developed to simulate costs from the perspective of the National Health Service in the UK and health outcomes ...
Giovanna Culeddu, Sofia Cividini, Ian Sinha, Sarah Donegan, Katie Rose, Olivia Fulton, Stephen Turner, Catrin Tudur Smith, Dyfrig A. Hughes, EINSTEIN collaborative group   +9 more
wiley   +1 more source

Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method [PDF]

, 2015
Background: Montelukast (MT) is a leukotriene D4 antagonist. It is an effective and safe medicine for the prophylaxis and treatment of chronic asthma. It is also used to prevent acute exercise-induced bronchoconstriction and as a symptomatic relief of ...
Abualhasan, Murad N, Bustami, Rana, Ghazal, Nadia, Mousa, Ayman, Watson, David G, Zaid, Abdel Naser   +5 more
core   +1 more source

Intermittent and Short‐Term Empirical Ruxolitinib Regimen for Steroid‐Refractory Flareups of Fibrodysplasia Ossificans Progressiva

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Fibrodysplasia ossificans progressiva (FOP) is an ultra‐rare genetic disorder with inflammation‐related flare‐ups resulting in catastrophic heterotopic ossification (HO). Janus‐associated kinase (JAK) inhibitors may have had a blocking effect on bone formation in controlling FOP flare‐ups by blocking multiple inflammatory signaling pathways ...
Rong‐Long Chen, Tzu‐Hsien Yang, Yun‐Hsin Wang, Jy‐juinn Shaw, Liuh‐Yow Chen   +4 more
wiley   +1 more source