Results 71 to 80 of about 1,713,699 (394)

A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress. [PDF]

, 2018
BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood.
Aschbacher, Kirstin, Burelle, Yan, Coccia, Michael, Cuillerier, Alexanne, Epel, Elissa S, Picard, Martin, Prather, Aric A, Puterman, Eli   +7 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

A qualitative study exploring depressed participants’ experiences of receiving Augmented Depression Therapy (ADepT)

BMJ Open
Objectives The current study aimed to explore participants’ views on the acceptability, impact and mechanisms of change of Augmented Depression Therapy (ADepT), a novel wellbeing-focused and recovery-oriented psychological therapy for depression.Design A
Rebecca Watson, Kim A Wright, Nigel Reed, Barney Dunn, Emily Widnall, Kalliopi Demetriou, Laura Warbrick, Katie Marchant, Nicole Geschwind, Isabella Magner-Parsons, Rachel Barter   +10 more
doaj   +1 more source

More than Money: Social Class, Income, and the Intergenerational Persistence of Advantage

Sociological Science, 2017
I provide a uniquely comprehensive empirical integration of the sociological and economic approaches to the intergenerational transmission of advantage.
Carina Mood
doaj   +1 more source

Effects of Probiotics on Cognitive Reactivity, Mood, and Sleep Quality

Frontiers in Psychiatry, 2019
Recent demonstration that probiotics administration has positive effects on mood state in healthy populations suggests its possible role as an adjunctive therapy for depression in clinical populations and as a non-invasive strategy to prevent depressive ...
A. Marotta, E. Sarno, A. Del Casale, M. Pane, L. Mogna, A. Amoruso, G. Felis, M. Fiorio   +7 more
semanticscholar   +1 more source

Daily mood, partner support, sexual interest, and sexual activity among adolescent women [PDF]

, 2005
This is a post print version of the article. The official published version can be accessed from the link below.Objective: to examine day-to-day associations of coitus, sexual interest, partner emotional support, negative mood and positive mood among ...
Barry P. Katz, Brown, Cynthia A. Graham, Donald P. Orr, Fortenberry, Fortenberry, Fortenberry, Fortenberry, Fortenberry, Frolich, Gillmore, Gold, Graber, Hensel, Impett, J. Dennis Fortenberry, Kirby, Leigh, M'Hamed Temkit, Morrison, Pinkerton, Shiffman, Shrier, Shulman, Sprecher, Van Whitlock, Wanzhu Tu   +26 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Non-randomised feasibility study of training workshops for Talking Therapies service high-intensity therapists to optimise depression and anxiety outcomes for individuals with co-morbid personality difficulties: a study protocol

Pilot and Feasibility Studies, 2023
Background The NHS Talking Therapies for Anxiety and Depression programme (‘TTad’; formerly Improving Access to Psychological Therapies ‘IAPT’) delivers high-intensity cognitive behavioural therapy (CBT) to over 200,000 individuals each year for common ...
Laura A. Warbrick, Barnaby D. Dunn, Paul A. Moran, John Campbell, David Kessler, Katie Marchant, Michelle Farr, Mary Ryan, Megan Parkin, Richard Sharpe, Katrina Turner, Mona Sylianou, Gemma Sumner, Emma Wood   +13 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Anyone Can Become a Troll: Causes of Trolling Behavior in Online Discussions

, 2017
In online communities, antisocial behavior such as trolling disrupts constructive discussion. While prior work suggests that trolling behavior is confined to a vocal and antisocial minority, we demonstrate that ordinary people can engage in such behavior
Berkowitz Leonard, Ceaparu Irina, Cheng Justin, Cheng Justin, Cho Daegon, Cialdini Robert B, Hutto Clayton J, Muchnik Lev, Pennebaker James W, Qing Li Tanya Beran, Raine Adrian, Salganik Matthew J, Zimbardo Philip G   +12 more
core   +1 more source