Results 241 to 250 of about 683,455 (344)

Catalyst‐Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds

open access: yesAdvanced Science, EarlyView.
A bioorthogonal rhodamine/PEG crosslinking strategy is introduced to engineer dense collagen hydrogels with high mechanical resilience and cytocompatibility. Integration with wet‐spinning enables the fabrication of uniaxially aligned, cell‐laden collagen filaments that activate mechanotransductive signaling and support functional muscle regeneration in
JuYeon Kim   +4 more
wiley   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

open access: yesAdvanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen   +8 more
wiley   +1 more source

Gender differences in symptom profiles of individuals being treated for mood disorders. [PDF]

open access: yesJ Mood Anxiety Disord
Weiss SJ   +6 more
europepmc   +1 more source

Niδ+ Atoms Anchored In Situ on Ultrathin Ni‐Phyllosilicate Nanosheet Ensure High‐Efficient CO2 Reduction into CO at Moderate‐Low Temperature

open access: yesAdvanced Science, EarlyView.
A novel supported Ni‐based catalyst, consisting of abundant Niδ+ atoms with low electron density anchored in situ on ultrathin Ni‐phyllosilicate nanosheet (a‐Niδ+−PSNS, 0< δ ≤1), achieve simultaneous outstanding CO2 conversion and CO selectivity. Their ultrathin nanosheet enables abundant anchored Niδ+ atoms to fully expose and disperse, which can ...
Ziluo Ding   +10 more
wiley   +1 more source

Information processing in mood disorders [PDF]

open access: yes, 2017
Roiser, Jonathan P, Sahakian, BJ
core  

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

open access: yesAdvanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan   +10 more
wiley   +1 more source

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