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Moonlighting proteins in sperm–egg interactions
Biochemical Society Transactions, 2014Sperm–egg interaction is a highly species-specific step during the fertilization process. The first steps consist of recognition between proteins on the sperm head and zona pellucida (ZP) glycoproteins, the acellular coat that protects the oocyte. We aimed to determine which sperm head proteins interact with ZP2, ZP3 and ZP4 in humans.
François M, Petit +2 more
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The role of proteomics in studies of protein moonlighting
Biochemical Society Transactions, 2014The increasing acceptance that proteins may exert multiple functions in the cell brings with it new analytical challenges that will have an impact on the field of proteomics. Many proteomics workflows begin by destroying information about the interactions between different proteins, and the reduction of a complex protein mixture to constituent peptides
Robert J, Beynon +3 more
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Bacterial Moonlighting Proteins and Bacterial Virulence
2011Implicit in the central dogma is the hypothesis that each protein gene product has but one function. However, over the past decade, it has become clear that many proteins have one or more unique functions, over-and-above the principal biological action of the specific protein.
Brian, Henderson, Andrew, Martin
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Mass spectrometry and the search for moonlighting proteins
Mass Spectrometry Reviews, 2004AbstractMass spectrometry has become one of the most important techniques in proteomics because of its use to identify the proteins found in different cell types, organelles, and multiprotein complexes. This information about protein location and binding partners can provide valuable clues to infer a protein's function.
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Metabolic phosphatase moonlights for proteins
Nature Cell Biology, 2022Scott A. Gerber, Arminja N. Kettenbach
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Proteins with neomorphic moonlighting functions in disease
IUBMB Life, 2011AbstractOne gene can encode multiple protein functions because of RNA splice variants, gene fusions during evolution, promiscuous enzyme activities, and moonlighting protein functions. In addition to these types of multifunctional proteins, in which both functions are considered “normal” functions of a protein, some proteins have been described in ...
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An overview of protein moonlighting in bacterial infection
Biochemical Society Transactions, 2014We are rapidly returning to a world in which bacterial infections are a major health issue. Pathogenic bacteria are able to colonize and cause pathology due to the possession of virulence factors such as adhesins, invasins, evasins and toxins. These are generally specifically evolved proteins with selective actions.
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MoonProt 3.0: An Update of the Moonlighting Proteins Database
Nucleic Acids Research, 2021Constance J Jeffery +2 more
exaly
Multifunctional Proteins: Moonlight Proteins
2019Sonyıllarda birçok proteinin birden fazla fonksiyona sahip olduğu bilgisi, bir gen- bir protein - bir fonksiyon fikrinin yerini almaya başlamıştır. Moonlightproteinler çok fonksiyonlu proteinlerin bir alt sınıfıdır. Moonlight proteinkavramı, tek bir polipeptid zincirinin çoklu biyokimyasal fonksiyonları yerinegetirmesini tanımlamaktadır. Bugün 300'
BİLGİCİ, Birşen +2 more
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Predicting Moonlighting Proteins from Protein Sequence
Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies, 2023Jing Hu, Yihang Du
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