Moonlighting Proteins: The Case of the Hexokinases [PDF]
Frontiers in Molecular Biosciences, 2021 Moonlighting proteins are defined as proteins with two or more functions that are unrelated and independent to each other, so that inactivation of one of them should not affect the second one and vice versa.
Carolina Rodríguez-Saavedra +5 more
doaj +7 more sources
Role of Moonlighting Proteins in Disease: Analyzing the Contribution of Canonical and Moonlighting Functions in Disease Progression [PDF]
Cells, 2023 The term moonlighting proteins refers to those proteins that present alternative functions performed by a single polypeptide chain acquired throughout evolution (called canonical and moonlighting, respectively).
Mario Huerta +7 more
doaj +4 more sources
Moonlighting Proteins: Diverse Functions Found in Fungi [PDF]
Journal of Fungi, 2023 Moonlighting proteins combine multiple functions in one polypeptide chain. An increasing number of moonlighting proteins are being found in diverse fungal taxa that vary in morphology, life cycle, and ecological niche.
Nicole J. Curtis +3 more
doaj +4 more sources
Why Study Moonlighting Proteins? [PDF]
Frontiers in Genetics, 2015 The examples above illustrate just some of the ways in which the continuing study of moonlighting proteins is important: developing novel therapeutics, identifying previously unknown cellular processes, elucidating the connections among biochemical pathways, understanding novel protein mechanisms, improving the prediction of protein functions, and ...
Constance J Jeffery
doaj +7 more sources
Pathogen Moonlighting Proteins: From Ancestral Key Metabolic Enzymes to Virulence Factors [PDF]
Microorganisms, 2021 Moonlighting and multitasking proteins refer to proteins with two or more functions performed by a single polypeptide chain. An amazing example of the Gain of Function (GoF) phenomenon of these proteins is that 25% of the moonlighting functions of our ...
Luis Franco-Serrano +9 more
doaj +4 more sources
Moonlighting proteins in medically relevant fungi [PDF]
PeerJ, 2022 Moonlighting proteins represent an intriguing area of cell biology, due to their ability to perform two or more unrelated functions in one or many cellular compartments.
Verania J. Arvizu-Rubio +2 more
doaj +5 more sources
Moonlighting Proteins in the Fuzzy Logic of Cellular Metabolism [PDF]
Molecules, 2020 The numerous interconnected biochemical pathways that make up the metabolism of a living cell comprise a fuzzy logic system because of its high level of complexity and our inability to fully understand, predict, and model the many activities, how they ...
Haipeng Liu, Constance J. Jeffery
doaj +4 more sources
A method for identifying moonlighting proteins based on linear discriminant analysis and bagging-SVM [PDF]
Frontiers in Genetics, 2022 Moonlighting proteins have at least two independent functions and are widely found in animals, plants and microorganisms. Moonlighting proteins play important roles in signal transduction, cell growth and movement, tumor inhibition, DNA synthesis and ...
Yu Chen, Sai Li, Jifeng Guo
doaj +2 more sources
Moonlighting Proteins Are Important Players in Cancer Immunology [PDF]
Frontiers in Immunology, 2021 Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, cancer and immune cells need to overcome the opponent’s defenses by activating more effective ...
Annalisa Adamo +5 more
doaj +2 more sources
IdentPMP: identification of moonlighting proteins in plants using sequence-based learning models [PDF]
PeerJ, 2021 Background A moonlighting protein refers to a protein that can perform two or more functions. Since the current moonlighting protein prediction tools mainly focus on the proteins in animals and microorganisms, and there are differences in the cells and ...
Xinyi Liu +6 more
doaj +3 more sources