Results 31 to 40 of about 5,705 (144)
Prereplication complex proteins get caught moonlighting.
PLoS Biology, 2022 In this issue of PLOS Biology, Lattmann and colleagues report a new function for proteins of the DNA prereplication complex promoting the anchor cell to invade through the basement membrane and initiate vulval development in Caenorhabditis elegans.
Hilary A Coller
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BMC Bioinformatics, 2021 Background Moonlighting proteins (MPs) are a subclass of multifunctional proteins in which more than one independent or usually distinct function occurs in a single polypeptide chain.
Farshid Shirafkan +4 more
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Moonlighting proteins: putting the spotlight on enzymes. [PDF]
Plant Signal Behav, 2018 AROGENATE DEHAYDRATASE2 (ADT2) is a member of the Arabidopsis thaliana ADT family. All members of this family act as arogenate dehydratases in phenylalanine biosynthesis, decarboxylating/dehydrating arogenate to phenylalanine. ADT2 is detected in stromules, and as a ring around the equatorial plane of dividing chloroplasts, indicating it has a second ...
Abolhassani Rad S +4 more
europepmc +4 more sources
The Expanding Landscape of Moonlighting Proteins in Yeasts. [PDF]
Microbiol Mol Biol Rev, 2016 SUMMARY Moonlighting proteins are multifunctional proteins that participate in unrelated biological processes and that are not the result of gene fusion. A certain number of these proteins have been characterized in yeasts, and the easy genetic manipulation of these microorganisms has been useful for a thorough analysis of some cases of ...
Gancedo C, Flores CL, Gancedo JM.
europepmc +5 more sources
Microorganisms, 2021 Moonlighting proteins are proteins with more than one function. During the past 25 years, they have been found to be rather widespread in bacteria. In Bacillus subtilis, moonlighting has been disclosed to occur via DNA, protein or RNA binding or protein ...
Inam Ul Haq, Sabine Brantl
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Frontiers in Oncology, 2022 Advanced prostate cancer (PRAD) patients have poor prognosis and rising morbidity despite the ongoing iteration of molecular therapeutic agents. As newly discovered proteins with several functions, Moonlighting proteins have showed an important role in ...
Wangli Mei +11 more
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Proteins moonlighting in tumor metabolism and epigenetics [PDF]
Frontiers of Medicine, 2021 AbstractCancer development is a complicated process controlled by the interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumor microenvironment. High plasticity in using diverse nutrients to adapt to metabolic stress is one of the hallmarks of cancer cells.
Lei, Lv, Qunying, Lei
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Redefining protein moonlighting
Oncotarget, 2015 We recently presented the first computational method for the large-scale identification of what we have termed "extreme multifunctional proteins" (EMF) [1]. These are proteins whose multiple functions are very dissimilar to one another. While obviously related to moonlighting proteins, we chose to coin a new term because we felt that the current ...
Chapple, Charles E, Brun, Christine
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Moonlighting genes harbor antisense ORFs that encode potential membrane proteins
Scientific Reports, 2023 Moonlighting genes encode for single polypeptide molecules that perform multiple and often unrelated functions. These genes occur across all domains of life. Their ubiquity and functional diversity raise many questions as to their origins, evolution, and
Kasman E. Thomas +2 more
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Lactoferrin, the Moonlighting Protein of Innate Immunity
International Journal of Molecular Sciences, 2023 Lactoferrin (Lf), a naturally occurring glycoprotein involved in innate immunity, was first discovered in bovine milk [...]
Antimo Cutone +2 more
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