Results 81 to 90 of about 5,878 (170)
The biomarkers of sarcopenia in elderly people
Journal of Physical Fitness and Sports Medicine, 2013 Sarcopenia is a very prevalent age-related decline in skeletal muscle mass and muscle strength, and it has a biologic basis and is a distinct clinical syndrome in elderly people that is associated with high risk for adverse health outcomes.
Kishiko Ogawa
doaj +1 more source
Synaptic Proteostasis in Health and Disease
Journal of Neurochemistry, Volume 170, Issue 10, October 2026.The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.CDO1 is a tumour suppressor in gastric cancer that directly binds PI3K p85α, disrupting p85α–p110α dimerization to inhibit the PI3K/AKT–THBS1 axis. Decitabine epigenetically restores CDO1 expression and exerts CDO1‐dependent anti‐tumour activity, synergizing with 5‐FU. Abstract Background As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1)
Fazhi Wang +6 more
wiley +1 more source
The multifunctional or moonlighting protein CD26/DPPIV
European Journal of Cell Biology, 2003 CD26/DPPIV can be considered a moonlighting protein because it is a multifunctional protein that exerts its different functions depending on cell type and intra- or extracellular conditions in which it is expressed. In the present review, we summarize all its known functions in relation to physiological and pathophysiological conditions. The protein is
Emil, Boonacker +1 more
openaire +2 more sources
Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins
Frontiers in Pharmacology, 2018 Adenosine is an endogenous purine nucleoside that acts in all living systems as a homeostatic network regulator through many pathways, which are adenosine receptor (AR)-dependent and -independent. From a metabolic point of view, adenosine deaminase (ADA)
Estefanía Moreno +23 more
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Frontiers in Molecular Neuroscience, 2018 Glycine and γ-aminobutyric acid (GABA) are the major determinants of inhibition in the central nervous system (CNS). These neurotransmitters target glycine and GABAA receptors, respectively, which both belong to the Cys-loop superfamily of pentameric ...
Vikram B. Kasaragod, Hermann Schindelin
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An alternative vaccine target for bovine Anaplasmosis based on enolase, a moonlighting protein. [PDF]
Front Vet Sci, 2023 Quiroz-Castañeda RE +2 more
europepmc +1 more source
A Moonlighting Protein Secreted by a Nasal Microbiome Fortifies the Innate Host Defense Against Bacterial and Viral Infections. [PDF]
Immune Netw, 2023 Kim G +14 more
europepmc +1 more source
The N-Acetylglucosamine Kinase from Yarrowia lipolytica Is a Moonlighting Protein. [PDF]
Int J Mol Sci, 2021 Flores CL, Ariño J, Gancedo C.
europepmc +1 more source
Plant cytoplasmic GAPDH: redox post-translational modifications and moonlighting properties
Frontiers in Plant Science, 2013 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous enzyme involved in glycolysis and shown, particularly in animal cells, to play additional roles in several unrelated non-metabolic processes such as control of gene expression and apoptosis.
Mirko eZaffagnini +4 more
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