Results 91 to 100 of about 785,945 (409)
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
A Dual Mechanism of Cognition and Emotion in Processing Moral-Vertical Metaphors
Frontiers in Psychology, 2018 A moral concept involves two main factors: moral cognition (indicated by morality) and emotion (indicated by emotionality). The cognitive mechanism underlying moral metaphors on the vertical dimension (e.g., moral-up, immoral-down) was investigated in ...
Dongxue Zhai +4 more
doaj +1 more source
Folk Platitudes as the Explananda of Philosophical Metaethics: Are They Accurate? And Do They Help or Hinder Inquiry? [PDF]
, 2017 The field of metaethics, the branch of moral philosophy that examines the nature and status of morality, is rich in theoretical diversity. Nonetheless, a majority of professional philosophers embrace a subset of theories that affirm the existence of ...
Sarkissian, Hagop
core
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Empirical evidence from a survey of the moral construction of university teachers in China [PDF]
MATEC Web of ConferencesThis study was conducted to explore the current situation and enhancement strategies of university teachers’ moral construction in China. Based on the cognitive and behavioral status of university teachers’ morality, we set up and distributed a survey ...
Liu Li, Xu Tingting
doaj +1 more source
Religiosity, morality and hardworking: Relationship models on diversity of religion in Indonesia [PDF]
Journal of Studies in Social Sciences and Humanities, 2022 This study aims to examine the model of religious relations, morality, and hard work among young people with the diversity of religions in Indonesia. Religion is valued by extrinsic and intrinsic religious orientations.
Dorothea Wahyu Ariani
doaj
Moral Luck and The Unfairness of Morality [PDF]
, 2019 Moral luck occurs when factors beyond an agent’s control positively affect how much praise or blame she deserves. Kinds of moral luck are differentiated by the source of lack of control such as the results of her actions, the circumstances in which she ...
Hartman, Robert
core
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source