Results 61 to 70 of about 695,624 (295)

Kant, Morality, and Hell [PDF]

, 2015
In this paper I argue that, although Kant argues that morality is independent of God (and hence, agrees with the Euthyphro), and rejects Divine Command Theory (or Theological Voluntarism), he believes that all moral duties are also the commands of God ...
GE Moore, I Kant, I Kant, I Kant, I Kant, I Kant, I Kant, J Austin, J Hall, J Rawls, L Denis, Plato, Plato, RG Swinburne, RJ Sullivan, S Darwall   +15 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Refleksi Pandangan Nietzsche terhadap Moralitas dan Kepentingan Diri

Humaniora, 2010
This research is a reflection, a result from author’s contemplative process, in reading one of the texts written by one of the western philosopher at the end of modernity, Friedrich Nietzsche.
Ferdinand Indrajaya
doaj   +1 more source

Understanding Catholic morality [PDF]

, 1999
Willems, Elizabeth. Understanding Catholic morality.
O\u27Connor, Thomas St. James
core   +1 more source

Female economic dependence and the morality of promiscuity [PDF]

, 2014
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ The Author(s) 2014.In environments in which female economic dependence on a male mate is higher, male parental investment is more essential. In such environments,
A Mesoudi, BB Smuts, BI Strassmann, D Symons, DP Schmitt, DP Schmitt, E Ostrom, FA Pedersen, G Paolacci, H Greiling, Isabel M. Scott, J Belsky, J Henrich, J Weeden, JA Simpson, JM Plavcan, JS Chisholm, L Fortunato, LH Beaudrot, M Buhrmester, M Daly, M Klein, M Pagel, MD Jennions, ME Price, ME Price, ME Price, Michael E. Price, MJ Crump, Nicholas Pound, PB Gray, R Kurzban, R Trivers, RD Alexander, RL Smith, S Gavrilets, S Stewart-Williams, SB Hrdy, SW Gangestad, SW Gangestad, SW Gangestad   +40 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Roman Catholic conceptualisation of morality: Its essence and distinctive character

Verbum et Ecclesia
Over the course of its history Catholicism has generated several different conceptions of morality. The early medieval church conceived morality primarily in terms of caritas and other virtues, the modern church generated a legalistic conception of ...
Stephen J. Pope
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Playing Around With Morality: Introducing the Special Issue on “Morality Play” [PDF]

, 2019
This special issue of Games and Culture focuses on the intersection between video games and ethics. This introduction briefly sets out the key research questions in the research field and identifies trends in the articles included in ...
Formosa, Paul, Ryan, Malcolm, Tulloch, Rowan   +2 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source