Results 71 to 80 of about 800,782 (389)

Law and morality in contemporary philosophy of law [PDF]

open access: yesFilozofija i Društvo, 2002
In this paper, author tries to analyze complex character of the relation between law and morality in contemporary law philosophy. There are three approaches to the issue of relation between law and morality: natural law theory (identity thesis ...
Stanković Dejan Vuk
doaj   +1 more source

The Function of Normative Process‐Requirements [PDF]

open access: yes, 2012
This paper discusses whether rationality, morality or prudence impose process‐requirements upon us. It has been argued that process‐requirements fulfil two essential functions within a system of rational, moral or prudential requirements. These functions
Fink, Julian
core   +1 more source

Moral Hybrids, Moral Relevance and Moral Particularism

open access: yesInformal Logic, 2012
Some of Jonathan Dancy's strongest arguments in support of moral particularism depend crucially upon the distinction he draws between three different kinds of relevance relations -- favourers, intensifiers and enablers. In this paper I generalize certain features of Dancy's account of the different roles that premises can play in moral argumentation ...
openaire   +5 more sources

The Morality of Moral Education

open access: yesAustralian Journal of Teacher Education, 1983
The Background - Moral Education as the Traditional Source of Personal Development. One of the abiding interests of moral philosophy is how some measure of competence at existence can not only be attained, but attained to an excellent degree. The idea that man is born imperfect but may so order his life that he approaches a more complete state of ...
Symes, C. T.   +2 more
openaire   +4 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Understanding Catholic morality [PDF]

open access: yes, 1999
Willems, Elizabeth. Understanding Catholic morality.
O\u27Connor, Thomas St. James
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

The Community of Nursing: Moral Friends, Moral Strangers, Moral Family [PDF]

open access: yes, 2008
Unlike bioethicists who contend that there is a morality common to all, H. Tristan Engelhardt (1996) argues that, in a pluralistic secular society, any morality that does exist is loosely connected, lacks substantive moral content, is based on the ...
Laabs, Carolyn A.
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

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