Results 71 to 80 of about 36,174 (247)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
A Developmental Perspective on the Origins of Morality in Infancy and Early Childhood
Frontiers in Psychology, 2018 Key constituents of morality emerge during the first 4 years of life. Recent research with infants and toddlers holds a promise to explain the origins of human morality.
Audun Dahl, Melanie Killen
doaj +1 more source
Virtual Morality: Transitioning from Moral Judgment to Moral Action?
PLOS ONE, 2016 The nature of moral action versus moral judgment has been extensively debated in numerous disciplines. We introduce Virtual Reality (VR) moral paradigms examining the action individuals take in a high emotionally arousing, direct action-focused, moral scenario. In two studies involving qualitatively different populations, we found a greater endorsement
Francis, Kathryn B. +6 more
openaire +5 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Empirical evidence from a survey of the moral construction of university teachers in China [PDF]
MATEC Web of ConferencesThis study was conducted to explore the current situation and enhancement strategies of university teachers’ moral construction in China. Based on the cognitive and behavioral status of university teachers’ morality, we set up and distributed a survey ...
Liu Li, Xu Tingting
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Determinism and the possibility of morality
Journal of Islamic Thought and Civilization, 2012 The possibility of morality in a causally determined physical world engages philosophers in a serious debate. Many philosophers think that morality is not possible in a world where everything, including human actions, is determined by antecedent causal ...
Dr. Zahoor H. Baber
doaj
Moral Distress, Moral Courage [PDF]
American Journal of Critical Care, 2015 Richard H, Savel, Cindy L, Munro
openaire +2 more sources