Results 181 to 190 of about 1,289,189 (314)
Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin +4 more
wiley +1 more source
Obstetrician and gynaecologist engagement in global surgery: adding necessary value to the field. [PDF]
Fallah PN +6 more
europepmc +1 more source
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera +12 more
wiley +1 more source
The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for discovering new antibiotics. Here, the authors identify a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and C4, inspired by the aquicidine gene cluster from Aquimarina.
Lei Li, Yiwen Zhou, Yuzhu Wu
wiley +1 more source
The relationship between expelled eggs, morbidity and age in a Schistosoma mansoni endemic setting in Uganda: Implications for current elimination policies. [PDF]
Lim RM +11 more
europepmc +1 more source
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng +6 more
wiley +1 more source
Evidence-based approach for intraabdominal drainage in pancreatic surgery: A systematic review and meta-analysis. [PDF]
Kodali R +9 more
europepmc +1 more source
This review highlights the synthesis and applications of magnetized cells (MCs) and magnetized scaffolds (MSs) in advancing bone tissue engineering strategies. It further demonstrates how magnetic particles (MPs) improve scaffold properties and how external magnetic fields enhance mesenchymal stem cell adhesion, proliferation, and osteogenic ...
Elio Cinar SanSegundo +3 more
wiley +1 more source

