Results 201 to 210 of about 1,390,280 (310)

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Operative Vaginal Delivery Compared to Cesarean After Failed Labor: A Population-Based Analysis of Neonatal and Maternal Outcomes. [PDF]

Children (Basel)
Cortes-Rojas Y, Forde B.
europepmc   +1 more source

Obesity Increases Morbidity and Mortality in Alcoholic Hepatitis

, 2019
Richard Parker, Su-Jeong Kim, GY Im, Jonathan Nahas, B Dhesi, Nikhil Vergis, Anubha Sinha, A. Ghezzi, Marco R Rink, Anne McCune, Guruprasad P. Aithal, Philip N. Newsome, CJ Weston, Anne F. Voor in ’t holt, Bin Gao   +14 more
openalex   +1 more source

Surgery for Morbid Obesity

Southern Medical Journal, 1979
openaire   +2 more sources

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Predictors of clinically relevant postoperative morbidity following curative intent surgical resection for non-small cell lung cancer. [PDF]

J Med Life
Tanase CB, Chitoran E, Rotaru V, Gullo G, Horvat T, Simion L.   +5 more
europepmc   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Giant Cell Tumor of the Sacrum: A Narrative Review of Management Challenges and Modalities. [PDF]

Healthcare (Basel)
Alaseem A, Aldosari ZA, Alduraibi AA, Alzahrani RK, AlNahari AS, AlAqeel M, Alshaygy I.   +6 more
europepmc   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Health outcomes and medical response during a military deployment in Iraq: a prospective observational study of morbidity, treatments, and evacuations. [PDF]

Sao Paulo Med J
Avellaneda DR, Iglesias MEL, Vallejo RBB, Gómez-Salgado J, López-López D, Labra C.   +5 more
europepmc   +1 more source