Results 61 to 70 of about 840,804 (341)

Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism

PLoS ONE, 2015
Carboxypeptidase E is a peptide processing enzyme, involved in cleaving numerous peptide precursors, including neuropeptides and hormones involved in appetite control and glucose metabolism.
S. Alsters, A. Goldstone, J. Buxton, A. Zekavati, A. Sosinsky, Andrianos M. Yiorkas, S. Holder, R. Klaber, N. Bridges, M. V. van Haelst, C. L. le Roux, A. Walley, R. Walters, Michael Mueller, A. Blakemore   +14 more
semanticscholar   +1 more source

The effect of foot orthoses on midfoot pain and the volume of bone marrow lesions in the midfoot: a randomized mechanism of action study

Arthritis Care &Research, Accepted Article.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain and MRI‐confirmed midfoot BMLs.
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction‐Associated Steatotic Liver Disease via a Galactose‐Modified Supramolecular Near‐Infrared Fluorescent Glycoprobe

Advanced Functional Materials, EarlyView.
A galactose‐modified supramolecular near‐infrared (NIR) glycoprobe, TCF‐FBN@Gal‐BSA, enables targeted delivery to the liver through the asialoglycoprotein receptor (ASGPR) and facilitates liver‐targeting fluorescence visualization of lipid droplets (LDs) in metabolic dysfunction‐associated steatotic liver disease (MASLD) mice.
Han‐Min Wang, Lei Dong, Qiu‐Lian Hao, Lu‐Lu Sun, Xin‐Rong Li, Yu‐Wei Yuan, Ming‐Ye Tang, Jin Gong, Yi Zang, Jia Li, Tony D. James, Xiao‐Peng He, Hai‐Hao Han   +12 more
wiley   +1 more source

Spinal Anesthesia in Morbidly Obese Patients: Risks, Benefits, and Future Perspectives

Инновационная медицина Кубани
Background: Morbid obesity is associated with unique physiological alterations that elevate the risk of perioperative complications. Spinal anesthesia represents a promising approach that may reduce the risks related to general anesthesia; however, its ...
T. K. Nematulloev, M. M. Matlubov
doaj   +1 more source

Hiatoplasty with crura buttressing versus hiatoplasty alone during laparoscopic sleeve gastrectomy [PDF]

, 2017
Introduction. In obese patients with hiatal hernia (HH), laparoscopic sleeve gastrectomy (LSG) with cruroplasty is an option but use of prosthetic mesh crura reinforcement is debated.
Badiali, Danilo, Balla, Andrea, Paganini, Alessandro M., Palmieri, Livia, Quaresima, Silvia, Seitaj, Ardit, Ursi, Pietro   +6 more
core   +3 more sources

The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery

Pharmaceutical Research, 2015
PurposeBariatric surgery is nowadays commonly applied as treatment for morbid obesity (BMI > 40 kg/m2). As information about the effects of this procedure on a drug’s pharmacokinetics is limited, we aimed to evaluate the pharmacokinetics of CYP3A probe ...
M. J. Brill, A. van Rongen, E. V. van Dongen, B. van Ramshorst, E. Hazebroek, A. Darwich, A. Rostami-Hodjegan, C. Knibbe   +7 more
semanticscholar   +1 more source

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

Advanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring, Brian P. Conlon, Edward A. Miao, Blossom Damania, Anna Mae Diehl, Pengda Liu   +14 more
wiley   +1 more source

The Relation of Complete Blood Count Parameters with Metabolic and Clinical Parameters in Overweight and Obese Children

Journal of Pediatric Research, 2021
Aim:This study aims to assess white blood cell count, platelet count, and platelet indices as a metabolic indicator in overweight, obese and morbidly obese children.Materials and Methods:One-hundred and thirty overweight, 341 obese, 188 morbidly obese ...
Ayşe Anık, Elif Çelik, Ahmet Anık
doaj   +1 more source

The complex interactions between obesity, metabolism and the brain [PDF]

, 2019
Obesity is increasing at unprecedented levels globally, and the overall impact ofobesity on the various organ systems of the body is only beginning to be fullyappreciated. Because of the myriad of direct and indirect effects of obesity causingdysfunction
Keller, Jeffrey Neil, Uranga, Romina Maria   +1 more
core   +1 more source

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, EarlyView.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source