Results 71 to 80 of about 849,526 (342)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Obesity Increases Risk‐Adjusted Morbidity, Mortality, and Cost Following Cardiac Surgery

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Despite the epidemic rise in obesity, few studies have evaluated the effect of obesity on cost following cardiac surgery. We hypothesized that increasing body mass index (BMI) is associated with worse risk‐adjusted outcomes and higher cost ...
Ravi K. Ghanta, Damien J. LaPar, Qianzi Zhang, Vishal Devarkonda, James M. Isbell, Leora T. Yarboro, John A. Kern, Irving L. Kron, Alan M. Speir, Clifford E. Fonner, Gorav Ailawadi   +10 more
doaj   +1 more source

The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications : a meta-analysis. [PDF]

, 2008
Obesity is rising in the obstetric population, yet there is an absence of services and guidance for the management of maternal obesity. This systematic review aimed to investigate relationships between obesity and impact on obstetric care. Literature was
Abrams, Andreasen, Baeten, Bergholt, Bianco, Bland, Bo, Callaway, Castro, Cedergren, Cedergren, Chauhan, Chu, Clark, Cnattingius, Cnattingius, Confidential Enquiry into Maternal and Child Health, Confidential Enquiry into Maternal and Child Health, Crane, Dempsey, Department of Health, Department of Health, Department of Health, Department of Health, Di Cianni, Doherty, Dresner, Edwards, Ehrenberg, Ehrenberg, Ekblad, Galtier-Dereure, Galtier-Dereure, Giuliani, Gore, Government Office for Science. FORESIGHT, Guelinckx, Gunderson, Hellerstedt, Hendler, Heslehurst, Heslehurst, Hibbard, Hulsey, Jensen, Jensen, Johnson, Kaiser, Kanagalingam, Kiran, Konje, Kramer, Kugyelka, Kumari, Lashen, Lewis, Linne, Lombardi, Lumme, Mancuso, Naeye, National Institute for Health and Clinical Excellence, Nucci, Ogunyemi, Olesen, Parmanum, Phithakwatchara, Ranta, Rantakallio, Rode, Rosenberg, Rossner, Sheiner, Shepard, Siega-Riz, Steinfeld, Vahratian, Waller, Wang, Weiss, Yekta   +80 more
core   +2 more sources

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Neuroanatomical Reflections of Childhood Obesity: Volumetric Analysis of the Pituitary Gland and Olfactory Bulb

Children
Introduction: Obesity is a rapidly increasing condition that leads to serious health issues. The sense of smell, one of the oldest senses related to energy metabolism, has been increasingly studied in relation to obesity.
Emel Hatun Aytaç Kaplan, Elif Bulut, Nazlı Gülsüm Akyel, Zümrüt Kocabey Sütçü, Şeyda Doğantan   +4 more
doaj   +1 more source

Multimodal Analgesia With Long-Acting Dinalbuphine Sebacate Plus Transversus Abdominis Plane Block for Perioperative Pain Management in Bariatric Surgery: A Case Report

Frontiers in Pharmacology, 2021
Laparoscopic bariatric surgery is increasingly performed in morbidly obese patients. However, post-surgical pain is common and is usually managed with classical opioids such as morphine and fentanyl.
Shih-Yuan Liu, Yi-Hong Ho, Chih-Shung Wong, Chih-Shung Wong, Chih-Shung Wong   +4 more
doaj   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Association of miR-34a and miR-143 levels with PPARγ gene expression in adipose tissues of non-diabetic adults

Journal of Physiological Anthropology, 2022
Background Peroxisome proliferator-activated receptor gamma (PPARγ) is a promising therapeutic molecule. Epigenetic mechanisms, including non-coding RNAs, regulate the expression level of the PPARγ gene. Objective We aimed to examine the PPARγ expression
Maryam Zarkesh, Kimia Tabaei, Mahdi Akbarzadeh, Afsoon Daneshafrooz, Azita Zadeh-Vakili   +4 more
doaj   +1 more source

Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity [PDF]

, 2018
Neurotensin (NT) is a 13-amino acid peptide localized in the neuroendocrine cells of the small intestine, which promotes fat absorption and fatty acids translocation in response to lipid ingestion. NT-knock-out mice fed with a high-fat diet are protected
Barchetta, Ilaria, Bertoccini, Laura, Capoccia, Danila, Cavallo, Maria, Ceccarelli, Valentina, Chiappetta, Caterina, Cimini, Flavia, Di Cristofano, Claudio, Leonetti, Frida, Melander, Olle, Orho-Melander, Marju, Silecchia, Gianfranco   +11 more
core   +2 more sources

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source