Results 141 to 150 of about 6,659,298 (299)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Second Conference on Lunar Bases and Space Activities of the 21st Century, volume 1 [PDF]

These papers comprise a peer-review selection of presentations by authors from NASA, LPI industry, and academia at the Second Conference (April 1988) on Lunar Bases and Space Activities of the 21st Century, sponsored by the NASA Office of Exploration and
Alred, John W., Bell, Larry S., Cintala, Mark J., Crabb, Thomas M., Durrett, Robert H., Finney, Ben R., Franklin, H. Andrew, French, James R., Greenberg, Joel S., Mendell, Wendell W.   +9 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Interspecies coexistence and environmental sensitivity in urban design: a qualitative study in Onex, Switzerland

[i2]: Investigación e Innovación en Arquitectura y Territorio
A qualitative analysis was conducted of data collected from the project L'étendue sauvage. remarquer le monde qui nous échappe, conducted in Onex, Switzerland, in the summer of 2022.
Aitor Frías-Sánchez, Estefanía Mompean Botias   +1 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Research-Creation and More-Than-Human Collaboration

Imaginations: Journal of Cross-Cultural Media Studies
This is a set of guiding principles for more-than-human collaboration in research-creation. As slippery terms with unclear boundaries, we must form practical and theoretical protocols to navigate multispecies activities that benefit the emerging ...
Oriana Confente
doaj   +1 more source

An Archive of Tensions: A Growing Collection of Challenges in More-Than-Human Design

Interactions
In this forum, we explore more-than-human design practices that consider the interactions and interdependencies between humans and nonhuman others, including animals, plants, water, bacteria, sensors, and data. — Anton Poikolainen Rosén and Sara Heitlinger, Editors
Dörrenbächer, Judith, Chow, Rosan, Yoo, Daisy, Eriksson, Eva; id_orcid 0000-0002-1013-6222   +3 more
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Designing Prosocial More-Than-Human Rhetoric within Experiential Futures

Proceedings of the 27th International Academic Mindtrek Conference
While prosocial behaviour is often described as behaviour intended to help and benefit others, it is primarily considered through an anthropocentric lens in that the others in question are principally humans. In this research, we consider designed systems whereby the prosocial benefits relate primarily to non-human actants, and although people may gain
Paul Coulton, Matthew Pilling, Michael Stead, Andrew Crabtree, Alan Chamberlain, Neelima Sailaja   +5 more
openaire   +1 more source