Antiviral Effect of 5′-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection [PDF]
Molecules, 2023 The understanding that zidovudine (ZDV or azidothymidine, AZT) inhibits the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 and that chalcogen atoms can increase the bioactivity and reduce the toxicity of AZT has directed our search for the discovery ...
Amanda Resende Tucci +13 more
doaj +2 more sources
Suppression of TGF-β/Smad2 signaling by GW788388 enhances DENV-2 clearance in macrophages. [PDF]
J Med Virol, 2022 Abstract Dengue fever, caused by the dengue virus (DENV‐1, −2, −3, and −4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue is correlated with high viraemia and cytokine storm, such as high levels of transforming growth factor‐β1 (TGF‐β1) in the patient's serum.
Teixeira GS +7 more
europepmc +2 more sources
Short-Term Functional and Morphological Changes in the Primary Cultures of Trigeminal Ganglion Cells [PDF]
Current Issues in Molecular Biology, 2022 Several studies have proved that glial cells, as well as neurons, play a role in pain pathophysiology. Most of these studies have focused on the contribution of central glial cells (e.g., microglia and astrocytes) to neuropathic pain.
Carla Pires Veríssimo +8 more
doaj +2 more sources
Ebselen and Diphenyl Diselenide Inhibit SARS-CoV-2 Replication at Non-Toxic Concentrations to Human Cell Lines [PDF]
Vaccines, 2023 The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the causative agent of the COVID-19 pandemic, a global public health problem.
Guilherme Wildner +9 more
doaj +2 more sources
In Vitro System for Studying Ilhéus Virus, a Neglected Arbovirus: Ultrastructural Characterization of Cytopathology, Morphology, and Morphogenesis [PDF]
VirusesIlhéus Virus (ILHV) was first detected in 1944 in Ilhéus, state of Bahia, northeast Brazil. During cellular infection, orthoflaviviruses induce cellular changes related both to the replication process, the formation of replication complexes, and to ...
Maycon Douglas do Nascimento Garcia +13 more
doaj +2 more sources
Microglia and macrophages in malignant gliomas: recent discoveries and implications for promising therapies. [PDF]
Clin Dev Immunol, 2013 Malignant gliomas are the most common primary brain tumors. Their deadliest manifestation, glioblastoma multiforme (GBM), accounts for 15% of all primary brain tumors and is associated with a median survival of only 15 months even after multimodal therapy.
da Fonseca AC, Badie B.
europepmc +2 more sources
Statine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV‑2 Mpro) [PDF]
Scientific ReportsCOVID-19 is a multisystemic disease caused by the SARS-CoV-2 airborne virus, a member of the Coronaviridae family. It has a positive sense single-stranded RNA genome and encodes two non-structural proteins through viral cysteine-proteases processing ...
Pedro Henrique R. de A. Azevedo +18 more
doaj +2 more sources
Clonal hematopoiesis: A challenge or opportunity in liquid biopsy? [PDF]
The Journal of Liquid BiopsyVeronica Aran
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Metabolomic Analysis and Antioxidant Potential of Tropical Propolis Nonpolar Extracts from Colombia
Journal of Food Processing and Preservation, Volume 2023, Issue 1, 2023., 2023 Bioactive compounds of natural matrices are of interest because of their application in the food and pharmaceutical industries. One important source of bioactives is propolis, a resinous biomass that bees make from the plants surrounding the hive. Regarding Colombian propolis, studies have mostly been directed towards identifying flavonoids and their ...
David Guillermo Piedrahita Márquez +6 more
wiley +1 more source
Uma introdução à história da embriologia
Filosofia e História da Biologia, 2022 Este trabalho apresenta um panorama do desenvolvimento do conceito de embrião desde a Antiguidade até o século XXI. A relevância em se discutir o que seria um embrião se acentua devido às preocupações e implicações éticas, religiosas, culturais e sociais
Isis Francisco Rolim Costa +1 more
doaj +1 more source