Results 1 to 10 of about 7,486 (147)

Antiviral Effect of 5′-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection [PDF]

Molecules, 2023
The understanding that zidovudine (ZDV or azidothymidine, AZT) inhibits the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 and that chalcogen atoms can increase the bioactivity and reduce the toxicity of AZT has directed our search for the discovery ...
Amanda Resende Tucci, Raquel Mello da Rosa, Alice Santos Rosa, Otávio Augusto Chaves, Vivian Neuza Santos Ferreira, Thamara Kelcya Fonseca Oliveira, Daniel Dias Coutinho Souza, Nathalia Roberto Resende Borba, Luciano Dornelles, Nayra Salazar Rocha, João Candido Pilar Mayer, João B. Teixeira da Rocha, Oscar Endrigo D. Rodrigues, Milene Dias Miranda   +13 more
doaj   +2 more sources

Ebselen and Diphenyl Diselenide Inhibit SARS-CoV-2 Replication at Non-Toxic Concentrations to Human Cell Lines [PDF]

Vaccines, 2023
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the causative agent of the COVID-19 pandemic, a global public health problem.
Guilherme Wildner, Amanda Resende Tucci, Alessandro de Souza Prestes, Talise Muller, Alice dos Santos Rosa, Nathalia Roberto R. Borba, Vivian Neuza Ferreira, João Batista Teixeira Rocha, Milene Dias Miranda, Nilda Vargas Barbosa   +9 more
doaj   +2 more sources

Short-Term Functional and Morphological Changes in the Primary Cultures of Trigeminal Ganglion Cells [PDF]

Current Issues in Molecular Biology, 2022
Several studies have proved that glial cells, as well as neurons, play a role in pain pathophysiology. Most of these studies have focused on the contribution of central glial cells (e.g., microglia and astrocytes) to neuropathic pain.
Carla Pires Veríssimo, Lionete Gall Acosta Filha, Fábio Jorge Moreira da Silva, Harrison Westgarth, Juliana De Mattos Coelho Aguiar, Bruno Pontes, Vivaldo Moura-Neto, Parisa Gazerani, Marcos F. DosSantos   +8 more
doaj   +2 more sources

Suppression of TGF-β/Smad2 signaling by GW788388 enhances DENV-2 clearance in macrophages. [PDF]

J Med Virol, 2022
Abstract Dengue fever, caused by the dengue virus (DENV‐1, −2, −3, and −4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue is correlated with high viraemia and cytokine storm, such as high levels of transforming growth factor‐β1 (TGF‐β1) in the patient's serum.
Teixeira GS, Andrade AA, Torres LR, Couto-Lima D, Moreira OC, Abreu R, Waghabi MC, de Souza EM.   +7 more
europepmc   +2 more sources

In Vitro System for Studying Ilhéus Virus, a Neglected Arbovirus: Ultrastructural Characterization of Cytopathology, Morphology, and Morphogenesis [PDF]

Viruses
Ilhéus Virus (ILHV) was first detected in 1944 in Ilhéus, state of Bahia, northeast Brazil. During cellular infection, orthoflaviviruses induce cellular changes related both to the replication process, the formation of replication complexes, and to ...
Maycon Douglas do Nascimento Garcia, Igor Pinto Silva Da Costa, Marcos Alexandre Nunes da Silva, Vivian Neuza dos Santos Ferreira, Ana Luisa Teixeira de Almeida, Gabriela Cardoso Caldas, Andressa Santos de Almeida, Ana Maria Bispo de Filippis, Natalia Fintelman-Rodrigues, Aline de Paula Dias da Silva, Marcelo Alves Ferreira, Thiago Moreno L. Souza, Alex Pauvolid-Corrêa, Debora Ferreira Barreto-Vieira   +13 more
doaj   +2 more sources

Statine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV‑2 Mpro) [PDF]

Scientific Reports
COVID-19 is a multisystemic disease caused by the SARS-CoV-2 airborne virus, a member of the Coronaviridae family. It has a positive sense single-stranded RNA genome and encodes two non-structural proteins through viral cysteine-proteases processing ...
Pedro Henrique R. de A. Azevedo, Priscila G. Camargo, Larissa E. C. Constant, Stephany da S. Costa, Celimar Sinézia Silva, Alice S. Rosa, Daniel D. C. Souza, Amanda R. Tucci, Vivian N. S. Ferreira, Thamara Kelcya F. Oliveira, Nathalia R. R. Borba, Carlos R. Rodrigues, Magaly G. Albuquerque, Luiza R. S. Dias, Rafael Garrett, Milene D. Miranda, Diego Allonso, Camilo Henrique da S. Lima, Estela Maris F. Muri   +18 more
doaj   +2 more sources

Clonal hematopoiesis: A challenge or opportunity in liquid biopsy? [PDF]

The Journal of Liquid Biopsy
Veronica Aran
doaj   +2 more sources

Metabolomic Analysis and Antioxidant Potential of Tropical Propolis Nonpolar Extracts from Colombia

Journal of Food Processing and Preservation, Volume 2023, Issue 1, 2023., 2023
Bioactive compounds of natural matrices are of interest because of their application in the food and pharmaceutical industries. One important source of bioactives is propolis, a resinous biomass that bees make from the plants surrounding the hive. Regarding Colombian propolis, studies have mostly been directed towards identifying flavonoids and their ...
David Guillermo Piedrahita Márquez, Marcelo Maraschin, Eva Regina Oliveira, Lady Viviana Camargo Ovalle, Consuelo Díaz-Moreno, Héctor Suárez-Mahecha, Charalampos Proestos   +6 more
wiley   +1 more source

Uma introdução à história da embriologia

Filosofia e História da Biologia, 2022
Este trabalho apresenta um panorama do desenvolvimento do conceito de embrião desde a Antiguidade até o século XXI. A relevância em se discutir o que seria um embrião se acentua devido às preocupações e implicações éticas, religiosas, culturais e sociais
Isis Francisco Rolim Costa, Gildo Magalhães   +1 more
doaj   +1 more source

Rurban landscapes: tension between rural practices and urban values in the morphogenesis of public spaces of seats of rural municipalities. A case study [PDF]

, 2009
O presente artigo interessa-se pelo esmaecimento das fronteiras entre o rural e o urbano na sede de pequenos municípios rurais. A partir de um estudo de caso - um município de menos de 3 mil habitantes - , postula-se que a inadequação da denominação ...
SOUZA, Gisela Barcellos de
core   +1 more source