Results 121 to 130 of about 881 (169)
Neuropsychopharmacological understanding for therapeutic application of morphinans [PDF]
Archives of Pharmacal Research, 2010 Morphinans are a class of compounds containing the basic structure of morphine. It is well-known that morphinans possess diverse pharmacological effects on the central nervous system. This review will demonstrate novel neuroprotective effects of several morphinans such as, dextromethorphan, its analogs and naloxone on the models of multiple ...
Eun-Joo Shin +2 more
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Enantioselective approach to morphinans
Tetrahedron Letters, 1990 Abstract Enantioselective synthesis of morphinan derivative 20 from 2,7-dimethoxynaphthalene has been achieved in twelve steps (11% overall yield).
Gilbert Revial +2 more
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Synthesis of Morphinans through Anodic Aryl‐Aryl Coupling
Chemical Record, 2021 The morphinans are an important class of structurally fascinating and physiologically important natural products as exemplified by the famous opium alkaloids of the morphine family. Although this class of secondary metabolites from the juice of the opium
Eisuke Sato, Till Opatz
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Some of the next articles are maybe not open access.
Expeditious Access to Morphinans by Chemical Synthesis
Angewandte Chemie - International Edition, 2022AbstractMorphinans are essential medicines derived entirely from poppy supply chains rendered increasingly volatile by climate change. Here, we report a seven‐step, asymmetric chemical synthesis of (−)‐codeine from simple materials that requires a total combined reaction time of fewer than 24 hours.
Lorenzo V White +2 more
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Programmed serial stereochemical relay and its application in the synthesis of morphinans
Chemical Science, 2017 A rationally designed, serial point-to-axial and axial-to-point stereoinduction and its integration into a multi-step and target-oriented organic synthesis was demonstrated in a novel chemical method to access morphinans and it is potentially applicable ...
David Y -K Chen
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Hydroxy‐morphinane. 12. Mitteilung. Die Konfiguration der Morphinane
Helvetica Chimica Acta, 1959AbstractIt has been shown that synthetic (–)‐3‐hydroxy‐N‐methyl‐morphinane (I) possesses the same steric configuration at the C‐atoms 9, 13 and 14 as the natural mor‐phine alkaloids, since it can be degraded to the known (–)‐cis‐ [2‐methyl‐carboxy‐cyclohexyl‐(l)]‐acetic‐acid.
H. Corrodi +4 more
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Synthesis of aminothiazole derived morphinans
Tetrahedron Letters, 2003Two aminothiazole derived morphinans 9 and 11 were prepared for our ongoing opioid ligands study. The synthesis was initiated from levorphanol 1, which was first triflated, and then subjected to Pd-catalyzed reduction followed by nitration. The resulting two nitrated isomers were characterized by analogy to known compounds.
Ao Zhang, John L Neumeyer
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Synthesis of morphinans with diversely functionalized benzoxazole moieties
Monatshefte Für Chemie, 2010 Zsuzsanna Gyulai +2 more
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Enzymatic transformations of morphinane alkaloids
Phytochemistry, 1982Abstract Horseradish peroxidase transforms morphinane alkaloids into N-oxides and morphine to pseudomorphine in the presence of hydrogen peroxide. The crude poppy enzyme fraction shows the same activities. The rates of reactions were influenced by phenolic compounds and their relation controlled by the concentration of hydrogen peroxide and the ...
Dezsö Vágújfalvi, Mária Petz-Stifter
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Oxy‐morphinane. (3. Mitteilung). Optisch aktive 3‐Oxy‐morphinane
Helvetica Chimica Acta, 1951Abstract3‐Oxy‐N‐alkyl‐morphinane wurden in die optischen Antipoden gespalten und diese in Äther und Ester übergeführt.
O. Schnider, A. Grüssner
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