Results 131 to 140 of about 881 (169)
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Anticonvulsant effects of new morphinan derivatives
Bioorganic & Medicinal Chemistry Letters, 2001We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats.
H C, Kim +7 more
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Syntheses of Pentacyclic Morphinan Analogs
Canadian Journal of Chemistry, 1975The synthesis of a series of morphinans with an additional aromatic or alicyclic ring fused to the 5,6 positions or an alicyclic ring fused to the 16,17 positions is described. The synthetic sequence involved elaboration of a 1,2,3,4,5,6-hexahydrobenz[f]isoquinoline or a quinolizidine, Grewe cyclization to a morphinan, and modification of the ...
James L. Douglas, Jacques Meunier
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Diversified electrophysiological properties of morphinan drugs in rats
General Pharmacology: The Vascular System, 19911. In in vivo and in vitro studies in rats, the effects of dextromethorphan (DM), dextrorphan (DX), and levorphanol (LV) were compared with those induced by kappa and sigma opiate agonists. 2. In rat hippocampal slices all the morphinans were able to pertubate the CAI hippocampal synaptic transmission, while only DX and LV affected the N-methyl-D ...
S, Sagratella +3 more
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Straightforward Assembly of the Octahydroisoquinoline Core of Morphinan Alkaloids
Organic Letters, 2010The octahydroisoquinoline core of morphinan was assembled starting from readily available arylcyclohexadienes. Three different approaches were developed, including a metal- and an acid-mediated Mannich type process and an anionic-mediated cyclization.
Julie, Dunet +4 more
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Aporphine and Morphinan Alkaloids
1968The aporphine and morphinan alkaloids can be conveniently considered together because they often occur together in the same plant, and also because in terms of structure they can both be derived from a benzylisoquinoline skeleton by additional ring closures:
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Biosynthesis of Morphinan Alkaloids
1985By the turn of the century a large number of alkaloids had been isolated, and investigators began to turn their attention to the ways by which these natural products were constructed in the living plant. Many interesting ideas were proposed during the next decades.
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Hydroxy‐morphinane. 7. Mitteilung. (−)‐3‐Hydroxy‐N‐allyl‐morphinan und verwandte Verbindungen
Helvetica Chimica Acta, 1956Abstract1‐(p‐Hydroxybenzyl)‐1, 2,3,4,5,6,7,8‐octahydro‐isoquinoline has been resolved into the optical antipodes, from which any desired optically active 3‐hydroxy‐morphinan substituted at the nitrogen atom can easily be obtained. The (‐)‐3‐hydroxy‐N‐allyl‐morphinan thus obtained as well as its ethers and ester counteract the effect of opiates and ...
J. Hellerbach, A. Grüssner, O. Schnider
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Morphinan Neuroprotection: New Insight into the Therapy of Neurodegeneration
Critical Reviews™ in Neurobiology, 2004Neuro-inflammation plays a pivotal role in numerous neurodegenerative disorders, such as Parkinson's disease (PD). Traditional anti-inflammatory drugs have limited therapeutic use because of their narrow spectrum and severe side effects after long-term use. Morphinans are a class of compounds containing the basic morphine structure.
Wei, Zhang +4 more
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Implication of tyramine in the biosynthesis of morphinan alkaloids in Papaver
Planta, 1987Doubly-labeled [(3)H, (14)C]tyrosines, [1-(13)C-]tyramine or [2-(14)C]tyramine, administered to the stems of intact Papaver somniferum L. plants, were found to be incorporated into the morphinan alkaloids of the plant with comparable efficiency. (3)H/(14)C ratios of alkaloids from plants fed the tyrosines were consistent with an almost equal conversion
M F, Roberts +3 more
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Hydroxy‐Morphinane. Mitteilung. Über ein Photooxydationsprodukt von (+)‐3‐Methoxy‐N‐methyl‐morphinan
Helvetica Chimica Acta, 1956AbstractPhotooxydation of (+)‐3‐methoxy‐N‐methyl‐morphinan hydrobromide (I, HBr, Romilar Roche) yields (−)‐3‐methoxy‐10‐oxo‐N‐methyl‐morphinan (II). The structure of the compound has been established. The introduction of a carbonyl group in position 10 is easily achieved in good yield also by oxydation with chromic acid. Whereas reduction of the 10‐oxo‐
O. Häfliger +4 more
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