Results 311 to 320 of about 235,160 (357)

The pharmacokinetics of morphine and morphine glucuronides in kidney failure

Clinical Pharmacology and Therapeutics, 1993
The pharmacokinetics of morphine and its glucuronide metabolites were investigated in three groups of patients with kidney failure (nondialyzed, receiving dialysis, and transplantation) and compared with a group of normal healthy volunteers. Patients in all three renal groups were undergoing surgical procedures (nondialyzed group undergoing ...
Duncan Trew, Richard H. Osborne, Maurice L. Slevin, Simon P. Joel, Kate Grebenik   +4 more
openaire   +3 more sources

Purity Profiles for Heroin, Morphine, and Morphine Hydrochloride

Journal of Pharmaceutical Sciences, 1973
Purity profiles were established for samples of heroin (diacetylmorphine), morphine, and morphine hydrochloride in order to define the scope of utility of each as qualitative and/or quantitative analytical standards. Systems for solubility analysis and high-pressure liquid chromatography were investigated. A heroin synthesis affording a product of high
Lee T. Grady, Sue E. Hays, Alice V. Kruegel   +2 more
openaire   +3 more sources

Unwanted effects of morphine‐6‐glucuronide and morphine

Anaesthesia, 2002
Summary The active metabolite of morphine, morphine‐6‐glucuronide (M6G), may have fewer unwanted effects than morphine. We randomly allocated 144 women to receive either M6G or morphine as part of general anaesthesia for day case gynaecological laparoscopy.
T. Milner, B. Ho, C. Cann, J. Curran
openaire   +3 more sources

The effects of prenatal morphine on the responsiveness to morphine and amphetamine

Pharmacology Biochemistry and Behavior, 1986
The effects of morphine administered to pregnant Sprague-Dawley rats on the schedule-controlled behavior of the offspring were examined. It was observed that both male and female adult rats exposed prenatally to morphine were tolerant to the disruptive effects of morphine on fixed-interval responding compared to age-matched controls.
David S. Gottesfeld, George C. Wagner, Mary Giorlando, Jamshid Rabii, Michael F. Jarvis   +4 more
openaire   +3 more sources

Concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide in serum and cerebrospinal fluid following morphine administration to patients with morphine-resistant pain

Pain, 1994
Recent studies have suggested that morphine-3-glucuronide (M3G) may antagonize the analgesic effects of morphine and morphine-6-glucuronide (M6G). To investigate this hypothesis, steady-state concentrations of morphine, M6G and M3G in serum and cerebrospinal fluid (CSF) were measured in 11 patients receiving chronic morphine therapy (9 orally and 2 ...
Kenneth F. Ilett, L. Peter Hackett, C. Roger Goucke   +2 more
openaire   +3 more sources

Morphine

2005
Abstract Morphine is the main pharmacologically active constituent of opium, the resin derived from the dried juice of the opium poppy, Papaver sominferum. Morphine was first introduced into clinical practice more than 200 years ago. Its effects are mediated by activating opioid receptors, mainly within the central nervous system (CNS ...
openaire   +1 more source

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

Journal of Pharmacology and Experimental Therapeutics, 1976
W. Martin, C. G. Eades, J. Thompson, R. E. Huppler, P. Gilbert   +4 more
semanticscholar   +1 more source

Morphine Antagonism

Nature, 1952
F H, SHAW, G A, BENTLEY
openaire   +3 more sources

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Nature, 1996
H. Matthes, R. Maldonado, F. Simonin, O. Valverde, S. Slowe, I. Kitchen, K. Befort, A. Dierich, M. L. Meur, P. Dollé, E. Tzavara, J. Hanoune, B. Roques, B. Kieffer   +13 more
semanticscholar   +1 more source

The Effect of Intrathecal Morphine Dose on Outcomes After Elective Cesarean Delivery: A Meta-Analysis

Anesthesia and Analgesia, 2016
P. Sultan, S. Halpern, E. Pushpanathan, S. Patel, B. Carvalho   +4 more
semanticscholar   +1 more source