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Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti +9 more
wiley +1 more source

Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Histone deacetylase 8 (HDAC8) is a clinically validated target in neuroblastoma, where isoform selective inhibition offers a strategy to suppress tumour growth while limiting off‐target toxicity. Hydroxamic acids remain the dominant zinc‐binding group (ZBG) in HDAC inhibitors but are also associated with metabolic instability, suboptimal ...
Nathan Long +3 more
wiley +1 more source

A Sustainable Borrowing Hydrogen Strategy in Natural Deep Eutectic Solvents for the N‐Alkylation of Amines From Alcohols

European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.
A sustainable, ligand‐free Pd‐catalyzed borrowing hydrogen protocol in a biodegradable hydrophobic natural deep eutectic solvent (NADES) (thymol/DL‐menthol) enables the N‐alkylation of primary amines with benzylic alcohols under mild, aerobic conditions, allowing efficient reuse of both catalyst and solvent for seven consecutive cycles. The hydrophobic
Maryam Saeb +5 more
wiley +1 more source

Radical Sampling Enabled Saturated N-Heterocycle Cyclization. [PDF]