Results 101 to 110 of about 18,579 (227)
Organocatalytic Formal (3+2+1)‐Cycloaddition of Allenoates, Michael Acceptors, and Carbaldehydes
The use of secondary amine Lewis base organocatalysts allows for the unprecedented activation of allenoates for formal (3+2+1)‐cycloadditions with Michael acceptors and aromatic carbaldehydes. ABSTRACT Employing secondary amines as covalently interacting Lewis basic organocatalysts allows for the activation of electron‐deficient allenes (allenoates ...
David Naderer +5 more
wiley +1 more source
Borylcyclopropanes: Synthetic Strategies and Applications
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner +5 more
wiley +1 more source
Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley +2 more sources
Genomic Surveillance and Molecular Evolution of Fungicide Resistance in European Populations of Wheat Powdery Mildew. [PDF]
Minadakis N +6 more
europepmc +2 more sources
Antibiotics improved human life, but bacterial resistance makes surfaces and packaging disinfection critical. Quaternary ammonium salts (QAS) represent a possible alternative. In this work, new bis‐cationic QAS from 2,4,6‐trichloro‐1,3,5‐triazine (bis‐TQAS) were synthesized, showing excellent inhibition against Klebsiella pneumoniae, Escherichia coli ...
Rachele Rampazzo +5 more
wiley +1 more source
Protoporphyrin IX derivatives bearing piperazine or morpholine substituents exhibit enhanced cellular retention and photodynamic activity in triple‐negative breast cancer cells. Structural modification promotes oxidative stress, alters mitochondrial membrane potential, and increases caspase‐3 activity, providing new structure–activity relationship ...
Maynne Duarte Suriani Franco +11 more
wiley +1 more source
Mechanochemical upcycling of bio‐ and fossil‐based polyesters with alcohols and amines using MeONa as the catalyst selectively produces synthetically useful diesters and diamides, giving only alcohols as byproducts. This green and efficient protocol is readily scalable and can be transferred to the upcycling of polyester‐based postconsumer waste ...
Divya Jain +5 more
wiley +1 more source
Modular assembly and property profiling of an expansive, shape-defined library of pentacyclic saturated N-heterocycles. [PDF]
Boschi E +12 more
europepmc +1 more source

