Results 91 to 100 of about 18,857 (217)

Specific patterns of changes in wheat gene expression after treatment with three antifungal compounds [PDF]

, 2018
The two fungicides azoxystrobin and fenpropimorph are used against powdery mildew and rust diseases in wheat (Triticum aestivumL). Azoxystrobin, a strobilurin, inhibits fungal mitochondrial respiration and fenpropimorph, a morpholin, represses ...
Isidore, Edwige, Keller, Beat, Pasquer, Frédérique, Zarn, Jürg   +3 more
core  

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, Volume 15, Issue 19, 22 May 2026.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Cyrene Dimethyl Acetal: Potential Alternative Solvent for Pd‐Catalyzed Homogeneous Aminocarbonylation of Iodo(hetero)arene Compounds

ChemPlusChem, Volume 91, Issue 5, May 2026.
Insert text for Table of Contents here. In this research, the synthesis of new Cyrene derivatives (Cyrene dimethyl acetal and Cyrene diethyl acetal) was accomplished, and the investigation of their physicochemical properties was completed. It was also shown after a detailed optimization study that Cyrene dimethyl acetal could be an appropriate ...
Attila Takács, Nuray Uzunlu Ince, Zoltán Medgyesi, Huda Hamed, László Kollár, Bence Mihalovics, László T. Mika   +6 more
wiley   +1 more source

Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of Novel 2‐Aminothiazole Derivatives as Potential FOXM1 Inhibitors for Triple‐Negative Breast Cancer Therapy and Structure‐Activity Relationship

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Triple Negative Breast Cancer (TNBC) is one of the most aggressive subtypes of breast cancer (BC), which is associated with a very poor prognosis. It is a broad category of tumors with a variety of biological, clinical, and morphological characteristics.
Khaled A. N. Abusharkh, Venhar Çınar, Alper Onder, Merve Sıkık, Mustafa Guzel, Zuhal Hamurcu, Bulent Ozpolat, Mehmet Ay, Ferah Comert Onder   +8 more
wiley   +1 more source

Potential Biological Targets of Anticancer Metal‐Based Drug Candidates: A Systematic Review

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT The discovery of Cisplatin marked the beginning of the metallodrug era in oncology. Despite their clinical success, platinum‐based compounds present important limitations, including drug resistance and systemic toxicity. These challenges have stimulated interest in alternative metal complexes capable of interacting with biomolecular targets ...
Allysson L. dos S. Ferreira, Bruna B. Dantas, Jailton De Souza‐Ferrari, Edilson B. Alencar Filho   +3 more
wiley   +1 more source

Differential Pulse Voltammetric Analysis of the New Psychoactive Drug 3β‐(4‐Fluorobenzoyloxy)tropane (fluorotropacocaine)

Electroanalysis, Volume 38, Issue 5, May 2026.
First voltammetric characterization of fluorotropacocaine and development of a selective DPV method for real‐sample analysis. A Design of Experiments (DoE)‐optimized Florisil‐SPE cleanup enables up to 50× enrichment and sensitive detection in urine, with high selectivity against excipients, endogenous components, and co‐occurring new psychoactive ...
Giancarla Alberti, Stefano Protti, Alessandra Bonanni, Azzurra Naso, Daniele Merli   +4 more
wiley   +1 more source

Small Molecule Inhibition of Mononegavirales RNA Polymerases

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT The order Mononegavirales includes several non‐segmented negative‐sense RNA viruses that are significant human pathogens, whose transcription and replication depend on multifunctional RNA‐dependent RNA polymerase (L protein). Recent discoveries in cryo‐electron microscopy (cryo‐EM) have elucidated the structures of these polymerases and their ...
Claire R. Cao, Meer Mohammed, Ge Yang, Dong Wang   +3 more
wiley   +1 more source

Un déterminant de l'innovation technique en agriculture : les coordinations sur le travail dans la production bananière [PDF]

The growth of the international market of the horticultural products is made possible by the globalization of an intensive mode of production in synthetic products which mobilizes salaried workers.
Bakry, F., Joubert, N., Marie, P., Temple, L.   +3 more
core   +3 more sources

ChemBang: Expanding the Chemical Space Around Small Molecules

Molecular Informatics, Volume 45, Issue 5, May 2026.
Schematic diagram of the underlying concepts behind ChemBang and the molecular generation process from a seed molecular structure by applying the three main categories of chemical transformations, namely, interchange of small substituents, replacement of ring systems, and scaffold enlargement by additional ring systems.
Diana Montes‐Grajales, Luca Menestrina, Ricard Garcia‐Serna, Jordi Mestres   +3 more
wiley   +1 more source

Fungicide resistance to morpholine and piperidine fungicides in barley and wheat powdery mildew Erysiphe graminis D.C. [PDF]

, 1999
This work was carried out to study the sensitivity of barley and wheat powdery mildew (Erysiphe graminis f.sp. hordei and E. graminis f.sp. tritici respectively) to morpholine fungicides. Morpholine fungicides are classified as
Zziwa, Miriam C. N.
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