Results 71 to 80 of about 17,730 (182)

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

The Therapeutic Potential of H2S‐Releasing Platforms in Cardiovascular Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.
The Therapeutic Potential of H2S‐Releasing Platforms. ABSTRACT Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H2S is a small gas with a short half‐life, making it extremely capable of penetrating ...
Tia N. Shorter, Elizabeth J. Brisbois
wiley   +1 more source

Von Richter Cinnolines Synthesis Revisited—Approach to Polysubstituted Cinnoline Derivatives as Important Scaffolds for Kinase Inhibitors

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
A revised von Richter cyclization of 2‐aminoalkyne precursors enables the synthesis of polysubstituted 4‐halocinnoline derivatives. By addressing the key challenge of hydrolytic instability, this catalyst‐free approach delivers scaffolds amenable to late‐stage C‐4 functionalization.
Krystof Skach, Milan Dejmek, Michal Sala, Radim Nencka   +3 more
wiley   +1 more source

Crystal structure of endo‐β‐1,6‐galactanase from Streptomyces avermitilis

Acta Crystallographica Section D, Volume 82, Issue 8, Page 962-971, August 2026.
The crystal structure of S. avermitilis endo‐β‐1,6‐galactanase belonging to GH30 subfamily 5 reveals the first structural framework for endo‐β‐1,6‐galactanase. The β‐1,6‐galactobiose‐bound complex identifies the catalytic subsites and a distal secondary sugar‐binding site, providing insight into β‐1,6‐galactan recognition.Endo‐β‐1,6‐galactanases ...
Zui Fujimoto, Naomi Kishine, Toshihisa Kotake, Satoshi Kaneko   +3 more
wiley   +1 more source

Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Mechanochemistry is redefining metal catalysis by controlling catalyst formulation, speciation, and deployment. This Review shows how milling, LAG, RAM, and TSE enable rapid metal‐complex assembly, distinctive catalytic manifolds, and scalable synthesis beyond solution chemistry.
Sourav Behera, Francesco Basoccu, Andrea Porcheddu   +2 more
wiley   +2 more sources

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source

Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley   +1 more source

Radical Sampling Enabled Saturated N-Heterocycle Cyclization. [PDF]

J Am Chem Soc
Cai Q, Bissonnette NB, Kim S, Knauber T, Chinigo GM, Blakemore DC, MacMillan DWC.   +6 more
europepmc   +1 more source

Calciphylaxis as a Rare Complication Associated with Pemigatinib Treatment-A Case Report. [PDF]

Curr Oncol
Čular K, Hamzić DT, Smiljanić Tomičević L, Buzina DŠ, Bradamante M, Simetić L, Bilić I, Belev B.   +7 more
europepmc   +1 more source

Design and Synthesis of Novel Isoflavene TANK‐Binding Kinase 1 Inhibitors With Anti‐Inflammatory Activity

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
TANK‐binding kinase 1 (TBK1) is a key regulator of innate immune signalling and an emerging therapeutic target. Here, we report the design, synthesis, and biological evaluation of isoflavonoid TBK1‐modulating analogues, achieving a sixfold enhancement in inhibition of TBK1 signalling relative to the clinically relevant idronoxil (IDX) parent scaffold ...
Valerio Falasca, W. Samantha N. Jayasekara, Dominic De Nardo, Daniel S. Wenholz, Michael P. Gantier, Naresh Kumar   +5 more
wiley   +1 more source