Results 71 to 80 of about 18,857 (217)

Novos métodos sintéticos de heterociclos de oxigénio e nitrogénio [PDF]

, 2021
Heterocyclic compounds have a considerable occurrence in the realm of the natural compounds being constituent parts of essential molecules for the sustain of living beings – sugars, amino acids, nucleobases, vitamins, etc.
Francisco, Telmo Neves
core  

Streamlined Synthesis and Structure–Activity Relationship Analysis of 2‐Amidothiophene‐3‐Carboxamides Targeting Influenza Polymerase PA‐PB1 Heterodimerization

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti, Alessia Zago, Andrea Astolfi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca, Oriana Tabarrini, Arianna Loregian, Serena Massari   +8 more
wiley   +1 more source

Practical Catalytic Cleavage of C(sp3)−C(sp3) Bonds in Amines [PDF]

, 2019
The selective cleavage of thermodynamically stable C(sp3)−C(sp3) single bonds is rare compared to their ubiquitous formation. Herein, we describe a general methodology for such transformations using homogeneous copper-based catalysts in the presence of ...
Beller, Matthias, Brgckner, Angelika, Junge, Kathrin, Leonard, David K., Li, Wu, Liu, Weiping, Rabeah, Jabor   +6 more
core   +1 more source

In‐situ‐Konstruktion von Imidazopyridinium‐Fluoreszenzlabels für Biokonjugationen

Angewandte Chemie, Volume 138, Issue 21, 18 May 2026.
Durch Chromophor‐Engineering von Isochinolinaldehyden entstehen TICT‐basierte fluorogene Farbstoffe für die In Situ Markierung unterschiedlicher (Bio‐)Moleküle mit großen Stokes‐Verschiebungen, die mit der Zellbildgebung kompatibel sind. ZUSAMMENFASSUNG Einfache, effiziente Transformationen fluorogenen Charakters, die unter biokompatiblen Bedingungen ...
Dongchen Du, László Albert, Milan Weitzel, Linda E. Eijsink, Elena R. Cotroneo, Dennis Marzin, Felipe Opazo, Nadja A. Simeth   +7 more
wiley   +1 more source

One‐Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade

Angewandte Chemie, Volume 138, Issue 19, 4 May 2026.
A sustainable electrochemical cascade enables the one‐pot synthesis of regioselectively halogenated N‐aryl amides from readily available amines and acyl halides under mild conditions. The method merges amidation and C─H halogenation in a single operational step, delivering broad substrate scope, high selectivity, and scalability, and provides an ...
Sudipta Ponra, Ruzal Sitdikov, Hasil Aman, Alyssio Calis, Gergely Laczkó, Virgile Rouffeteau, Maxime R. Vitale, Imre Pápai, Oscar Verho   +8 more
wiley   +2 more sources

Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers. [PDF]

The knowledge captured in patent and scientific research literature stimulates new ideas and fosters new drug development efforts. Manufacturers and entrepreneurs dedicated to the sale of 'research chemicals' and/or new psychoactive substances (NPS) also
Banks, Banks, Banks, Banks, Barceloux, Bauer, Beckett, Brandt, Brandt, Carlström, Clarke, Czoty, Davies, Hampson, Howell, Hu, Kumazawa, McLaughlin, McLaughlin, Mellar, Miles, Rothman, Rothman, Rudolph, Sheldrick, Sitte, Xiao   +26 more
core   +1 more source

In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation

Angewandte Chemie International Edition, Volume 65, Issue 21, 18 May 2026.
Chromophore engineering of isoquinoline aldehydes generates TICT‐based fluorogenic dyes for in situ labeling of diverse (bio)molecules with large Stokes shifts compatible with cell imaging. ABSTRACT Simple, efficient transformations of fluorogenic nature that proceed under biocompatible conditions without the formation of byproducts are of high ...
Dongchen Du, László Albert, Milan Weitzel, Linda E. Eijsink, Elena R. Cotroneo, Dennis Marzin, Felipe Opazo, Nadja A. Simeth   +7 more
wiley   +1 more source

Synthesis, Functionalization, and Reactivity of Vinyl Sulfondiimidamides

Angewandte Chemie, Volume 138, Issue 19, 4 May 2026.
Combining unsymmetrical sulfurdiimide reagents (R‐NSN‐R1) and Grignard reagents, followed by oxidative amination, delivers a series of vinyl sulfondiimidamides. Reactivity with cysteine and lysine derivatives is shown, and the cysteine reactivity is mapped in detail. Variation of the two imidic N‐substituents can be used to tune reactivity of these new
Katherine G. Rodden, Agamemnon E. Crumpton, Samuel E. Dalton, Michael A. Clegg, Michael C. Willis   +4 more
wiley   +2 more sources

Un déterminant de l'innovation technique en agriculture : les coordinations sur le travail dans la production bananière [PDF]

, 2008
Working Paper MOISASumary The growth of the international market of the horticultural products is made possible by the globalization of an intensive mode of production in synthetic products which mobilizes salaried workers.
Bakry, Frédéric, Joubert, Nelly, Marie, Philippe, Temple, Ludovic   +3 more
core   +2 more sources

Merging Micellar Catalysis and C–H Activation: Silver‐Free Direct Arylation of Fluoroarenes in Water

ChemSusChem, Volume 19, Issue 9, 14 May 2026.
We have developed the first silver‐free protocol for a palladium‐catalyzed direct arylation in water under micellar conditions enabling the coupling of diverse pyridine and fluoroarene derivatives. This method combines the sustainability of aqueous media with the efficiency of C–H activation, obviating the need for organic co‐solvents or stoichiometric
Federico Belnome, Kristóf N. Garami, Zoltán Varga, Judith Mihály, Pascal Hauk, Tamás Hergert, György M. Keserű, Fabrice Gallou, Joanna Wencel‐Delord, Péter Ábrányi‐Balogh   +9 more
wiley   +1 more source