Results 61 to 70 of about 17,730 (182)

Interaction Analysis using the Cambridge Structural Database – rapid access to intermolecular hydrogen‐bond frequencies and uses for coformer selection

Acta Crystallographica Section B, EarlyView.
We describe a coformer selection tool that uses knowledge of functional group interactions found in the Cambridge Structural Database to quickly identify complementary molecules to the target.A new methodology to perform virtual coformer screening, utilising data gathered on hydrogen‐bonding interactions present in the organic subset of the Cambridge ...
Joanna S. Stevens, Andrew G. P. Maloney, Elna Pidcock   +2 more
wiley   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Unveiling contrasting iron efficiency strategies in common bean (Phaseolus vulgaris L.) genotypes under iron deficiency

Plant Biology, EarlyView.
Common bean genotypes differ in their iron acquisition through distinct Strategy I responses and root exudation patterns. Abstract Iron (Fe) deficiency in food crops, particularly on calcareous soils, limits productivity and human nutrition. This study investigated two common bean (Phaseolus vulgaris) genotypes, Guaymí (high Fe‐accumulating, HI) and ...
F. X. Rucamumihigo, U. Ludewig, A. Hernández‐Pridybailo, I. Cakmak, N. J. Maywald   +4 more
wiley   +1 more source

A Perspective of Soy Isoflavones on Analytical, Biological, and Chemical Attributes

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT This review covers key aspects of soybean (Glycine max), with a particular focus on its isoflavone content and biological properties. Soybeans maintain their position as both a nutraceutical and a pharmaceutical crop, with a broad range of dietary items used worldwide, including soy milk, fermented soy products, and various dietary supplements.
Sristy Suman, Joydeep Chatterjee, Gaurav Joshi, Raj Kumar, Muhammad Wahajuddin   +4 more
wiley   +1 more source

Flipping the Card With Enantiodivergent Organocatalysis

Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre, Alessio Carioscia, Alessandro Brusa, Armando Carlone   +3 more
wiley   +1 more source

Halide/Pseudohalide Anion Regulation of Polar Structure and Glass‐Forming Ability Toward Polar Hybrid Glass‐Ceramic

Aggregate, Volume 7, Issue 8, August 2026.
Systematic anion engineering from halide to pseudohalide (Cl− → Br− → I− → NCS−) in a family of cadmium(II)‐based organic‐inorganic hybrids drives a progressive transition from centrosymmetric to polar structure, depresses melting point, reduces fragility index, and enhances glass‐forming ability, ultimately affording a polar hybrid glass‐ceramic with ...
Ding‐Chong Han, Yu Wang, Zi‐Yi Ren, Zi‐Luo Fang, Ying‐Guang Li, Yi‐Wen Fan, Hai‐Bin Yu, Hao Zhuo, Ya‐Nan Fan, Shuai Chen, Biao Luo, Wei‐Xiong Zhang   +11 more
wiley   +1 more source

Genomic Surveillance and Molecular Evolution of Fungicide Resistance in European Populations of Wheat Powdery Mildew. [PDF]

Mol Plant Pathol
Minadakis N, Jigisha J, Cornetti L, Kunz L, Müller MC, Torriani SFF, Menardo F.   +6 more
europepmc   +2 more sources

Catalytic Deuteration of Amines in Water (D2O) With Ir, Ru, and Rh Pentamethylcyclopentadienyl Dioxime Complexes

ChemistryEurope, Volume 4, Issue 8, August 2026.
A new family of pentamethylcyclopentadienyl (C5Me5, Cp*) iridium(III), rhodium(III), and ruthenium(III) complexes bearing bidentate 1,2‐dioxime ligands was developed and their catalytic performances were evaluated in the hydrogen‐borrowing‐type H/D exchange of amines using D2O as both solvent and deuterium source. Iridium derivatives achieved excellent
Francesco Taglieri, Maria Edith Casacchia, Anna Pisani, Assunta Cortese, Stefano Zacchini, Marcello Crucianelli, Fabio Marchetti, Andrea Di Giuseppe, Lorenzo Biancalana   +8 more
wiley   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Three Component Thio‐ and Carboboration of Alkynes: A Modular Route to Functionalised Bicyclic Boronates

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
Three‐component thio‐ and carbo‐boration reactions to form functionalised benzoxaborinines and benzazaborinines are reported. The nucleophile scope includes thioethers, thiols, and (hetero)arenes. Mechanistic studies revealed a disparity between thioboration using thioethers and using thiols.
Laura Winfrey, Gary S. Nichol, Stephen P. Thomas, Dominic R. Willcox, Michael. J. Ingleson   +4 more
wiley   +2 more sources