Results 71 to 80 of about 1,054,458 (269)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Molecular Analysis and Morphological Characterization of Tor sp. using DNA Barcode COI from Telaga Rambut Monte, Blitar, East Java, Indonesia

Biotropika: Journal of Tropical Biology
The genus Tor (Cyprinidae) comprises highly diverse freshwater fishes widely distributed in Southeast Asia, including Indonesia. However, information on Tor species in several regions remains limited.
Ayu Elysia Damaya, Calista Naya Rabbani, Cahya Ajeng Valenta Tresna Sulung, Rusdianto Rusdianto, Endik Deni Nugroho, Noorhidayah Binti Mamat, Dwi Anggorowati Rahayu   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Five-Year Slaughterhouse-Based Surveillance of Echinococcus granulosus in Sheep from Yili, Northwest Xinjiang, China

Pathogens
Background: Cystic echinococcosis (CE) remains a significant zoonotic burden in the pastoral regions of China. Yili Prefecture in Xinjiang is a high-risk area, yet comprehensive data are lacking on the prevalence and molecular characteristics of ...
Cairen, Xiaoli Zhang, Li Zhang, Kalibixiati Aimulajiang, Batubayier Daoerji, Daoerji Namuka, Baoping Guo, Rongsheng Mi, Liying Wang   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Morphological, yield and quality variability among the accessions of Plumbago zeylanica

Electronic Journal of Plant Breeding, 2017
Forty two accessions of Plumbago zeylanica were collected and evaluated for morphological, yield and quality traits. The results revealed that the accession Pz 27 registered the highest mean value for plant height (178.33cm) and fresh weight of root (518.
L. Nalina, K. Shanthanu, K. Rajamani, A. John Joel, Tushar Dhanani, Raghuraj Singh and, Satyanshu Kumar   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Comparative Study of the Main Courtyard-Facing Facade A Case Study of Two Traditional Houses in Sulaymaniyah and Sanandaj

Sulaimani Journal for Engineering Sciences
Traditional Kurdish architecture in the cities of Sulaymaniyah and Sanandaj represents a living mirror of social and cultural identity, with houses with main courtyards forming the heart of residential life, and the facades overlooking them becoming the ...
Sakar Sardar Mohammed Salih , Amjad Muhammad Ali Qaradaghi   +1 more
doaj   +1 more source