Results 81 to 90 of about 1,049,873 (268)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Morphology of “Selaginella” [PDF]

Nature, 1877
IN consequence of my not having expressed myself sufficiently fully, Prof. Thiselton Dyer somewhat misapprehends my remarks respecting Selaginella and Carex, to which he is good enough to reply in NATURE (vol. xv. p. 489); and I shall be glad of an opportunity of explaining the nature of the comparison that I drew between the reproductive organs in ...
openaire   +1 more source

Microstructural and Mechanical Characterizations of Natural Long Alfa Fibers Obtained with Different Extractions Processes

Journal of Natural Fibers, 2017
This study investigates the morphological changes and tensile properties of Alfa fibers extracted mechanically after two treatments namely water retting and alkali treatment.
A. Boukhoulda, F. B. Boukhoulda, H. Makich, M. Nouari, B. Haddag   +4 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Philosophical morphology

Disputatio philosophica : International Journal on Philosophy and Religion, 2009
In the paper authors present, examine, and test elements of the vital idea of the philosophical morphology as a method and a technique of philosophical investigation. The paper consists of some applications mostly concerning the method applied by L. Wittgenstein in PI and related later works, and of a series of examples concerning daily phenomena.
Lukin, Josip, Krkač, Kristijan
openaire   +3 more sources

Comparative Study of the Main Courtyard-Facing Facade A Case Study of Two Traditional Houses in Sulaymaniyah and Sanandaj

Sulaimani Journal for Engineering Sciences
Traditional Kurdish architecture in the cities of Sulaymaniyah and Sanandaj represents a living mirror of social and cultural identity, with houses with main courtyards forming the heart of residential life, and the facades overlooking them becoming the ...
Sakar Sardar Mohammed Salih , Amjad Muhammad Ali Qaradaghi   +1 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Affixation in Morphology

, 2020
Affixation is the morphological process that consists of adding an affix (i.e., a bound morpheme) to a morphological base. It is cross-linguistically the most common process that human languages use to derive new lexemes (derivational affixation) or to adapt a word’s form to its morphosyntactic context (inflectional affixation ...
openaire   +2 more sources