Results 71 to 80 of about 5,145,073 (302)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Comparative Morphology of the Wing Base Structure Illuminates Higher-Level Phylogeny of Holometabola

Insects
Phylogenetic relationships among Holometabola have been the subject of controversy. The value of the wing base structure in phylogenetic analysis has been demonstrated but remains largely underexplored and scarce in studies of Holometabola.
Chenjing Zhao, Mengting Huang, Ding Yang, Xingyue Liu   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

First Detection and Molecular Identification of Rhabditis (Rhabditella) axei from the Chinese Red Panda (Ailurus styani)

Pathogens
Rhabditis (Rhabditella) axei is a predominantly free-living nematode commonly found in sewage systems and decomposing organic matter. While primarily saprophytic, it has been documented as an opportunistic pathogen in human urinary and gastrointestinal ...
Chanjuan Yue, Wanjing Yang, Dunwu Qi, Mei Yang, James Edward Ayala, Yanshan Zhou, Chao Chen, Xiaoyan Su, Rong Hou, Songrui Liu   +9 more
doaj   +1 more source

Morphological Study on Quadruplets by Cephalometric and Model Analyses

The Bulletin of Tokyo Dental College, 2007
Clarifying the genetic factors involved in maxillofacial growth and development is very important in orthodontic treatment planning and prognosis. However, few dental studies have examined multiple births. The present orthodontic evaluation was conducted using orthodontic data from a set of quadruplets.
Shino, Tamami, Kawabata, Kaoruko, Nojima, Kunihiko, Nishii, Yasushi, Sueishi, Kenji, Yamaguchi, Hideharu   +5 more
openaire   +3 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Morphological Filters Based on Motif Combination for Functional Surface Evaluation [PDF]

, 2011
Regarded as the complement of commonly used mean-line based filters, morphological filters are more function oriented. They are relevant to geometrical properties of surfaces and offers better results for functional prediction of surfaces.
Lou, Shan, Jiang, Xiang, Scott, Paul J.
core   +3 more sources

Morphological analyses of histological images using fractal

In order to assist the decision of the pathologist in cancer diagnosis, a new algorithm using morphological analyses based on fractal geometry is investigated.
Sims A, Sharif B, Marghani K, Dlay S
core   +3 more sources

A Fast Algorithm for Morphological Filters [PDF]

, 2010
In surface metrology, M-system (Mean-line filtering system) and E-system (Envelope filtering system) are two filtering approaches. Although M-system has been the dominant choice and played an important role in manufacturing control, Morphological filters,
Lou, Shan, Xiangqian Jiang, Jiang, Xiangqian, Jiang, Xiang, Paul J Scott, Shan Lou, Scott, Paul J., Lou, Shan; id_orcid   +7 more
core   +1 more source