A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
VIABILITY CHARACTERISTICS AND PHYSIOLOGICAL BEHAVIORS IN CABBAGE SEEDS IN DEPENDS ON STAGE OF MATURITY [PDF]
The main purposes of the present study were to establish the changes during different stage of maturity and development of cabbage seed as well as earliest behaviors of viability and harvesting data.
Nikolay Panayotov, Nevena STOEVA
doaj
The effect of irrigation with wastewater fish ponds on the quality of peanut, (Arahis hypogeae)
The research was carried out at Alsen research center of the General Authority for Fisheries in the Banias region–Tartus Governorate - during two agricultural seasons 2018-2019, in order to study the effect of irrigation with fish culture effluent on ...
Ali S. Othman +3 more
doaj +1 more source
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Some morphological characteristics of turkish shepherd dogs raised in breeder conditions various countries [PDF]
Aim: This research was conducted to compare some morphological characteristics of shepherd dogs, phenotypically similar to Turkish shepherd dogs, raised in public areas in Turkey, Iran, Azerbaijan and Uzbekistan.
Cafer Tepeli +4 more
doaj
A theoretical insight into morphological operations in surface measurement by introducing the slope transform [PDF]
As one of the tools for surface analysis, morphological operations, although not as popular as linear convolution operations (e.g. the Gaussian filter), are really useful in mechanical surface reconstruction, surface filtration, functional simulation etc.
Lou, Shan +6 more
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Habitat-specific morphological variation among threespine sticklebacks (Gasterosteus aculeatus) within a drainage basin [PDF]
MMW was funded by a Natural Environment Research Council studentship (NERC, UK) awarded to PJBH. AJWW was supported by a DVC Grant from the University of Sydney.Habitat-specific morphological variation, often corresponding to resource specialization, is ...
Hart, Paul J. B. +18 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source

