Results 131 to 140 of about 2,513,970 (297)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

MORPHOLOGICAL VARIATIONS IN FETAL AND CADAVERIC LIVER: AN OBSERVATIONAL STUDY

Introduction: The liver is the largest abdominal organ and undergoes complex development from the fourth week of gestation. Aim & Objectives: This study aimed to observe and compare morphological variations, such as accessory fissures, accessory ...
Dr. Susmita Saha, Dr. Prachi Saffar Aneja, Ms. Akanksha Deshwal, Dr. Manish S Ahuja   +3 more
core   +1 more source

Morphological variations of the cervical vertebrae in samples of South African black and white population groups [PDF]

, 2016
The frequency of variations in nine morphological features of the cervical column in a South African (S.A.) black and white example of human skeletons was investigated to determine whether there Was a greater degree of morphological variability in the
Asvat, Riaze
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Diurnal variation in corneo-scleral morphology

Journal of Optometry
Purpose To characterize diurnal variations in scleral morphological parameters and assess correlations between lifestyle habits and variations in these parameters.Methods This prospective observational study enrolled healthy adult participants. Corneo-scleral morphology was evaluated at five standardized timepoints (9:00, 11:30, 14:00, 16:30, and 19:00)
Laura Barberán-Bernardos, Miguel Ángel Ariza-Gracia, David P. Piñero   +2 more
openaire   +2 more sources

Provenance Variations in Morphological Characteristics of Acacia karroo Hayne Seedlings

, 2004
Page(s):12 (2), 219-234,11Ref.This study was carried out to assess the extent of intraspecific variation in morphological characteristics of the seedlings of Acacia karroo.
Khalil, A.A. M., Ibrahim, A.M., Abdelkheir, R. M.   +2 more
core  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Morphological variation and phylogenetic position of Vatica rassak ( Dipterocarpaceae ) based on the trn L- trn F region

Plant and Fungal Systematics
Vatica rassak is one of the most exploited species of the genus Vatica for its wood and resin. The species exhibits high morphological variations across their range of distribution that crosses the border of the Wallace’s line.
Kusumadewi Sri Yulita, Elisa Andriyani, Arida Susilowati, Henti Hendalastuti Rachmat, Nawwall Arrofaha, Susila Susila, Asep Hidayat, Irsyad Kamal   +7 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source