Results 101 to 110 of about 2,387,418 (315)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis

open access: yesScientific Reports, 2017
Despite the associations between diabetic complications and vascular endothelial dysfunction, a direct therapeutic method targeting endothelial dysfunction remains poorly characterized.
Kumiko Taguchi   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Understanding the Effects of Au Morphology on CO2 Electrocatalysis [PDF]

open access: yes, 2018
Toward efficient CO2 electrocatalysis for CO production, nanostructured Au catalysts have been extensively investigated by the morphology control of oxygen plasma-induced Au islands, oxide-derived Au, Au nanowires (NWs), Au nanoparticles (NPs ...
정유성, 백서인, 염민선
core  

The Angiogenic Potential of DPSCs and SCAPs in an In Vivo Model of Dental Pulp Regeneration

open access: yesStem Cells International, 2017
Adequate vascularization, a restricting factor for the survival of engineered tissues, is often promoted by the addition of stem cells or the appropriate angiogenic growth factors.
Petra Hilkens   +5 more
doaj   +1 more source

Genes and tooth development: reviewing the structure and function of some key players.

open access: yesBrazilian Journal of Oral Sciences, 2015
Similar to many other embryonic organs, the mammalian tooth development relies largely on epithelial-mesenchymal interactions. Tooth development may be divided in multiple stages, where the number, size and type of teeth are sequentially determined ...
Raquel Mantuaneli S. Caminaga   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Morphology 2000 Selected papers from the 9th Morphology Meeting, Vienna, 24-28 February 2000 [PDF]

open access: yes
This volume focuses on two main topics: comparative morphology (i.e. cross-linguistic analysis, including typology, dialectology and diachrony) and psycholinguistics (i.e. on-line processing, off-line experiments, child language).
Bendjaballah, Sabrina.   +3 more
core  

The Morphology of Flutes [PDF]

open access: yes, 1970
Measurements were taken on 1511 flutes from various localities in Eastern North America. Over 85% of the flutes recorded are from the Cloridorme Formation (Ordovician) of North-Eastern Quebec.
Pett, John
core  

Acknowledgement to Reviewers of Journal of Functional Morphology and Kinesiology in 2019

open access: yesJournal of Functional Morphology and Kinesiology, 2020
Journal Of Functional Morphology And Kinesiology Editorial
doaj   +1 more source

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