Results 111 to 120 of about 1,843,388 (341)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Unsupervised Learning of Morphology without Morphemes [PDF]

arXiv, 2002
The first morphological learner based upon the theory of Whole Word Morphology Ford et al. (1997) is outlined, and preliminary evaluation results are presented. The program, Whole Word Morphologizer, takes a POS-tagged lexicon as input, induces morphological relationships without attempting to discover or identify morphemes, and is then able to ...
arxiv  

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

3D projection analysis: characterizing the morphological stability of nearby open clusters [PDF]

arXiv
Context. The study of open cluster morphology is pivotal for exploring their formation and evolutionary processes. Aims. We manage to assess the morphological stability of 105 nearby open clusters within tidal radii on the X-Y, X-Z, and Y-Z planes of the heliocentric Cartesian coordinate system, utilizing member catalogs from the literature. Meanwhile,
arxiv  

Better Character Language Modeling Through Morphology [PDF]

arXiv, 2019
We incorporate morphological supervision into character language models (CLMs) via multitasking and show that this addition improves bits-per-character (BPC) performance across 24 languages, even when the morphology data and language modeling data are disjoint.
arxiv  

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

FEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla, Faiza Abbas, Luigia Rossi, Mauro Magnani, Sara Biagiotti   +4 more
wiley   +1 more source

Acquisition of Inflectional Morphology in Artificial Neural Networks With Prior Knowledge [PDF]

arXiv, 2019
How does knowledge of one language's morphology influence learning of inflection rules in a second one? In order to investigate this question in artificial neural network models, we perform experiments with a sequence-to-sequence architecture, which we train on different combinations of eight source and three target languages.
arxiv  

Astrocyte morphology

Trends in Cell Biology
Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal feature of astrocytes is their complex and visually enchanting morphology, referred to as bushy, spongy, and star-like. A central precept of this review is that such complex morphological shapes evolved to allow astrocytes to contact and signal with diverse ...
Baldwin, Katherine T, Murai, Keith K, Khakh, Baljit S   +2 more
openaire   +3 more sources

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Descriptive macroscopic anatomy of the central nervous system six-banded armadillo (Euphractus sexcintus, Linnaeus, 1758) and nine-banded armadillo (Dasypus novemcinctus, Linnaeus, 1758)

Jornal Interdisciplinar de Biociências, 2016
Armadillos of the species Dasypus novemcinctus and Euphractus sexcintus are xenarthrico is a mammal that inhabits fields and has several eating habits.
João Victor Silva Araújo, Maria Michele Araújo de Sousa Cavalcante, Paulo César de Jesus Gonçalves, Sérgio Paulo Lima Guerra, Andrezza Braga Soares da Silva, Airton Mendes Conde Júnior   +5 more
doaj