Results 161 to 170 of about 2,701,117 (260)

Multimodal single-cell dataset of juvenile rat neocortical interneurons-Morphology, whole-cell patch electrophysiology and histological slices. [PDF]

Front Neurosci
Toledo-Rodriguez M, Shi Y, Meystre J, La Mendola D, Ranjan R, Soltuzu L, Pezzoli M, Perin RC, Markram H.   +8 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Congenital and Breed-Associated Vertebral Anomalies in Dogs and Cats: Developmental Anatomy, Genetic Determinants, and Biological Significance. [PDF]

Life (Basel)
Covașă CT, Grădinaru AC.
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Comparative morphology of male reproductive apparatus in pipefishes and seahorses: implication on the syngnathids fertilization strategy. J. Morphol

, 2010
BIAGI F, FRANZOI P, CORSO, Gavina, CARCUPINO M. . COMPARATIVE MORPHOLOGY OF MALE REPRODUCTIVE APPARATUS IN PIPEFISHES AND SEAHORSES IMPLICATION ON THE SYNGNATHIDS FERTILIZATION S.T.R.A.T.E.G.Y. J. MORPHOL   +3 more
core  

Brain morphology network profiles in male and female youth with autism. [PDF]

Cereb Cortex
Safari N, Levy I, Zhang A, Agarwal C, Cortes JM, Pelphrey KA, Van Horn JD, Rasero J.   +7 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Age-aware multimetric MRI assessment of patellofemoral dysplasia in a symptomatic nine-year-old girl without documented dislocation: A case report. [PDF]

Radiol Case Rep
Choumad S, Ebedda A, Mohamed El Hacen A, El Mabrouk F, Belkouchi L, Allali N, Chat L, El Haddad S.   +7 more
europepmc   +1 more source