A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket +14 more
wiley +1 more source
A comparison of vestigial zeugopodal and autopodal elements in ruminants and their potential use in establishing phylogenetic relationships [PDF]
Hamilton, Charles H. +3 more
core +1 more source
Objective This research article aims to describe the prevalence, associations and health‐related quality‐of‐life (HRQoL) impact of mucocutaneous features of SLE. Methods Data from the Asia‐Pacific Lupus Collaboration cohort were analysed (2013‐2021). Mucocutaneous activity (MC‐A) items were rash, alopecia and mucosal ulcers; defined by the SLEDAI‐2K ...
Amanda M Saracino +42 more
wiley +1 more source
Correction: Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in the fungal pathogen Histoplasma. [PDF]
PLOS Biology Staff.
europepmc +1 more source
Pediatric Neoplasia: Morphology and Biology [PDF]
openaire +1 more source
New giraffoid fossils from the later Early Miocene Lothidok Formation (West Turkana, Kenya): Implications for early giraffoid diversity [PDF]
Grossman, Ari +2 more
core +1 more source
Biology and External Morphology of Immature Stages of the Butterfly,Diaethria candrena candrena [PDF]
Fernando Maia Silva Dias +3 more
openalex +1 more source

