Results 41 to 50 of about 455,228 (309)

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

First Record of Huchen hucho hucho (Linnaeus 1758) in the Grza River: Human-Caused Introduction from its Native Habitat in Serbia

Croatian Journal of Fisheries
Huchen or Danube salmon Hucho hucho (Linnaeus 1758) is one of the largest salmonid species in the world and the largest species native to the Danube basin in Europe. In Serbia, this species inhabits the Drina river system, as well as the upper reaches of
Sokolović Vojislav D., Marić Ana D., Nikolić Vera P., Kanjuh Tamara A., Škraba Jurlina Dubravka V., Simonović Predrag D.   +5 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Biological and morphological aspects of spiny eel Mastacembelus mastacembelus (Banks and Solander, 1794) inhabiting Al-Tharthar canal / Samarra, Iraq

Tikrit Journal for Agricultural Sciences, 2023
    Biological aspects (size composition, length-weight relationship, condition factor, food habit and reproduction season), and morphological of Mastacembelus mastacembelus inhabiting Al-Tharthar canal studied during the period from April to September ...
Nehad Wahab
doaj   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy

Frontiers in Cellular and Infection Microbiology, 2019
Visceral leishmaniasis (VL), caused by digenetic protozoa of the genus Leishmania, is the most severe form of leishmaniasis. Leishmania infantum is one of the species responsible for VL and the disease caused is considered a zoonosis whose main reservoir
Ana Alice Maia Gonçalves, Jaqueline Costa Leite, Lucilene Aparecida Resende, Reysla Maria da Silveira Mariano, Patricia Silveira, Otoni Alves de Oliveira Melo-Júnior, Helen Silva Ribeiro, Diana Souza de Oliveira, Diogo Fonseca Soares, Thaiza Aline Pereira Santos, Alexandre Ferreira Marques, Alexsandro Sobreira Galdino, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Denise da Silveira-Lemos, Rodolfo Cordeiro Giunchetti   +15 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence

Cell Death and Disease
During aging, muscle regenerative capacities decline, which is concomitant with the loss of satellite cells that enter in a state of irreversible senescence.
Yaiza Potes, Juan C. Bermejo-Millo, Catarina Mendes, José P. Castelão-Baptista, Andrea Díaz-Luis, Zulema Pérez-Martínez, Juan J. Solano, Vilma A. Sardão, Paulo J. Oliveira, Beatriz Caballero, Ana Coto-Montes, Ignacio Vega-Naredo   +11 more
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source