Results 61 to 70 of about 2,798,587 (305)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Automated analysis of neuronal morphology, synapse number and synaptic recruitment [PDF]

, 2011
peer reviewedThe shape, structure and connectivity of nerve cells are important aspects of neuronal function. Genetic and epigenetic factors that alter neuronal morphology or synaptic localization of pre- and post-synaptic proteins contribute ...
de Bruijn, P., Hjorth, J. J. Johannes, Susanne Eijgenraam, Ooyen, A. van, Hjorth, J.J. Johannes, Bruijn, P. de, Eijgenraam, Susanne, Sabine K. Schmitz, Wouter Veldkamp, van Ooyen, A., Arjen van Ooyen, Veldkamp, W., Hjorth, J.J.J., Christina Georgiou, Joemai, R.M.S., Wijntjes, Rick, van Ooyen, Arjen, Eijgenraam, S., Toonen, R.F.; id_orcid, Verhage, Matthijs, de Jong, A.P.H., Toonen, R.F., Georgiou, C., Jong, A.P.H. de, Veldkamp, W.J.H., Joemai, Raoul M.S., de Jong, Arthur P. H., SCHMITZ, Sabine, Joemai, Raoul M. S., Veldkamp, Wouter, Petra de Bruijn, L. Niels Cornelisse, Ruud F. Toonen, Toonen, Ruud F., Schmitz, Sabine K., Schmitz, S.K., Cornelisse, L.N., J.J. Johannes Hjorth, Verhage, M., Georgiou, Christina, Raoul M.S. Joemai, Wijntjes, R., Matthijs Verhage, Cornelisse, L. Niels, de Bruijn, Petra, Rick Wijntjes, Arthur P.H. de Jong, Veldkamp, Wouter J. H., de Jong, Arthur P.H.   +48 more
core   +1 more source

Seasonal variation of mortality, detectability, and body condition in a population of the adder (Vipera berus)

Ecology and Evolution, 2019
We analyzed seasonal variation in mortality rates in adult males and females of the European adder (Vipera berus), using data collected during a 13‐year capture–recapture study (2005–2017) in a large population.
Dirk Bauwens, Katja Claus
doaj   +1 more source

Tenascins in Retinal and Optic Nerve Neurodegeneration

Frontiers in Integrative Neuroscience, 2017
Tenascins represent key constituents of the extracellular matrix (ECM) with major impact on central nervous system (CNS) development. In this regard, several studies indicate that they play a crucial role in axonal growth and guidance, synaptogenesis and
Jacqueline Reinhard, Lars Roll, Andreas Faissner   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Building a path in cell biology

, 2012
Setting up a new lab is an exciting but challenging prospect. We discuss our experiences in finding a path to tackle some of the key current questions in cell biology and the hurdles that we have encountered along the ...
Cheeseman, Iain M, Voeltz, Gia
core   +1 more source

Inner ear morphology in the Atlantic molly Poecilia mexicana [PDF]

, 2011
Fishes show an amazing diversity in hearing abilities, inner ear structures, and otolith morphology. Inner ear morphology, however, has not yet been investigated in detail in any member of the diverse order Cyprinodontiformes.
Plath, Martin, Hess, Martin, Schulz-Mirbach, Tanja   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Influence of incubation temperature on morphology and locomotion performance of Leatherback (Dermochelys coriacea) hatchlings [PDF]

, 2010
The journey of Leatherback (Dermochelys coriacea (Vandelli, 1761)) hatchlings from nest to the sea is a vulnerable life-history stage. Studies have shown that nest incubation temperatures influence hatchling morphology and locomotor performance, which ...
Downie, J.R., Mickelson, L.E.
core   +1 more source

p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence

Cell Death and Disease
During aging, muscle regenerative capacities decline, which is concomitant with the loss of satellite cells that enter in a state of irreversible senescence.
Yaiza Potes, Juan C. Bermejo-Millo, Catarina Mendes, José P. Castelão-Baptista, Andrea Díaz-Luis, Zulema Pérez-Martínez, Juan J. Solano, Vilma A. Sardão, Paulo J. Oliveira, Beatriz Caballero, Ana Coto-Montes, Ignacio Vega-Naredo   +11 more
doaj   +1 more source