Results 61 to 70 of about 539,840 (309)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

TRIZ Evolution Trends in Biological and Technological Design Strategies [PDF]

, 2009
Organised by: Cranfield UniversityThe concept of evolution in technology and biology is discussed. It appears that most of the evolution trends in technology and biology result from different development strategies.
Bogatyrev, N. R., Bogatyreva, O. A.
core  

p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence

Cell Death and Disease
During aging, muscle regenerative capacities decline, which is concomitant with the loss of satellite cells that enter in a state of irreversible senescence.
Yaiza Potes, Juan C. Bermejo-Millo, Catarina Mendes, José P. Castelão-Baptista, Andrea Díaz-Luis, Zulema Pérez-Martínez, Juan J. Solano, Vilma A. Sardão, Paulo J. Oliveira, Beatriz Caballero, Ana Coto-Montes, Ignacio Vega-Naredo   +11 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Reproductive and larval biology of the sub-Antarctic hermit crab Pagurus comptus reared in the laboratory [PDF]

, 2006
Fecundity, hatching rhythm, and the planktotrophic larval development of the hermit crab Pagurus comptus from sub-Antarctic waters of the Beagle Channel (Tierra del Fuego) were studied under controlled laboratory conditions of temperature, light cycle ...
Lovrich, Gustavo Alejandro, Thatje, Sven, Lovrich, Gustavo A.   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The control of mitochondrial morphology and dynamics in Arabidopis thaliana

, 2012
Mitochondria are ubiquitous eukaryotic organelles which carry out a range of essential functions, most notably the production of ATP through the process of oxidative phosphorylation.
Scott, Iain
core  

An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy

Frontiers in Cellular and Infection Microbiology, 2019
Visceral leishmaniasis (VL), caused by digenetic protozoa of the genus Leishmania, is the most severe form of leishmaniasis. Leishmania infantum is one of the species responsible for VL and the disease caused is considered a zoonosis whose main reservoir
Ana Alice Maia Gonçalves, Jaqueline Costa Leite, Lucilene Aparecida Resende, Reysla Maria da Silveira Mariano, Patricia Silveira, Otoni Alves de Oliveira Melo-Júnior, Helen Silva Ribeiro, Diana Souza de Oliveira, Diogo Fonseca Soares, Thaiza Aline Pereira Santos, Alexandre Ferreira Marques, Alexsandro Sobreira Galdino, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Denise da Silveira-Lemos, Rodolfo Cordeiro Giunchetti   +15 more
doaj   +1 more source