Results 91 to 100 of about 49,566 (282)
SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT
Bone metastasis is a devastating consequence of lung cancer.Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li +10 morewiley +1 more sourceSirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages
Advanced Science, EarlyView.The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai +7 morewiley +1 more sourceSensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair
Advanced Science, EarlyView.Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...Jiaying Liu, Ting Zhang, Yuqing Mu, Lili Li, Ju Jin, Kevin J Dudley, Wendong Gao, Donglin Cai, Fuhua Yan, Lan Xiao, Yin Xiao +10 morewiley +1 more sourceLiver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction
Advanced Science, EarlyView.Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu +15 morewiley +1 more sourceMorphological variability and distribution of the exotic Asian Mesocyclops thermocyclopoides (Copepoda: Cyclopoida): in the Neotropical region</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Zoologia (Curitiba)</i>, 2011 </span><br><span class="r_content">From a series of biological samples collected from different freshwater environments in Costa Rica, Central America, the exotic Asian cyclopoid Mesocyclops thermocyclopoides Harada, 1931 was identified.</span><br><span class="r_sub"><i>Eduardo Suárez-Morales<span id="ma_6" style="display:none">, Nancy F Mercado-Salas, Álvaro Morales-Ramírez</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_6')">+2 more</a></small></i></span><br><small><a href="https://doaj.org/article/fb56d6a6cfaa48878b53e3df7d540546" target="_blank" rel="nofollow" title="doaj.org/article/fb56d6a6cfaa48878b53e3df7d540546">doaj</a> </small> <div id="more_6" style="display:none"><a href="/sci_redir.php?doi=10.1590%2FS1984-46702011000500016" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1590/S1984-46702011000500016'); alert('Copied the doi');">copy doi</a> <small>(10.1590/S1984-46702011000500016)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_6')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/advs.202519249" target="_blank" rel="nofollow">Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Advanced Science, EarlyView.</i></span><br><span class="r_content">This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...</span><br><span class="r_sub"><i>Rishi Man Chugh<span id="ma_7" style="display:none">, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_7')">+11 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/advs.202519249?mi=2or9o2m&af=R&AllField=morphometrics&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/advs.202519249?mi=2or9o2m&af=R&AllField=morphometrics&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_7" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Fadvs.202519249" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/advs.202519249'); alert('Copied the doi');">copy doi</a> <small>(10.1002/advs.202519249)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_7')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/advs.202519586" target="_blank" rel="nofollow">Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Advanced Science, EarlyView.</i></span><br><span class="r_content">Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.</span><br><span class="r_sub"><i>Poorvi Subramanian<span id="ma_8" style="display:none">, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_8')">+7 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/advs.202519586?mi=2or9o2m&af=R&AllField=morphometrics&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/advs.202519586?mi=2or9o2m&af=R&AllField=morphometrics&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Fadvs.202519586" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/advs.202519586'); alert('Copied the doi');">copy doi</a> <small>(10.1002/advs.202519586)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.3389/fmars.2024.1391752" target="_blank" rel="nofollow">Characterising a potential nearshore nursery ground for the blackchin guitarfish (Glaucostegus cemiculus) in Ma’agan Michael, Israel</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Frontiers in Marine Science</i></span><br><span class="r_content">The blackchin guitarfish Glaucostegus cemiculus has suffered severe declines and regional extirpation throughout its known distributions. While this species and its relative, the common guitarfish Rhinobatos rhinobatos, have been described in the ...</span><br><span class="r_sub"><i>Barak Azrieli<span id="ma_9" style="display:none">, Eynav Cohen, Leigh Livne, Debra Ramon, Anat Tsemel, Eyal Bigal, Eli Shemesh, Ziv Zemah-Shamir, Adi Barash, Dan Tchernov, Aviad Scheinin</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_9')">+10 more</a></small></i></span><br><small><a href="https://doaj.org/article/9af7d60fc3a24c5089d6b3c421e465a9" target="_blank" rel="nofollow" title="doaj.org/article/9af7d60fc3a24c5089d6b3c421e465a9">doaj</a> </small> <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.3389%2Ffmars.2024.1391752" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.3389/fmars.2024.1391752'); alert('Copied the doi');">copy doi</a> <small>(10.3389/fmars.2024.1391752)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.13102/sociobiology.v66i3.4338" target="_blank" rel="nofollow">A Worker-Like Female of Myrmica sabuleti (Meinert, 1861) (Hymenoptera: Formicidae: Myrmicinae) in a Pitfall Trap with Five Mermithids (Nematoda: Mermithidae) Protruding from the Gaster</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Sociobiology</i>, 2019 </span><br><span class="r_content">A worker-like female of Myrmica sabuleti (Meinert, 1861), pitfall-trapped near Jena, Germany, in late summer 2016, was infested by five postparasitic juvenile mermithids. They poked out of the ant´s gaster as a trail of seven filaments of various lengths.</span><br><span class="r_sub"><i>Florian M. Steiner<span id="ma_10" style="display:none">, Günter Köhler, Bernhard Seifert, Wolfgang Arthofer, Birgit Schlick-Steiner, Alfred Buschinger</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_10')">+5 more</a></small></i></span><br><small><a href="https://doaj.org/article/74a3f5fa5a484ca1923347e4540ff62d" target="_blank" rel="nofollow" title="doaj.org/article/74a3f5fa5a484ca1923347e4540ff62d">doaj</a> </small> <div id="more_10" style="display:none"><a href="/sci_redir.php?doi=10.13102%2Fsociobiology.v66i3.4338" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.13102/sociobiology.v66i3.4338'); alert('Copied the doi');">copy doi</a> <small>(10.13102/sociobiology.v66i3.4338)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_10')">+1 more source</a></small><br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-morphology/" class="suggestion"onclick="show_loader();"><b>morphology</b></a><br/><a href="/q-conservation/" class="suggestion"onclick="show_loader();"><b>conservation</b></a><br/><a href="/q-nematode/" class="suggestion"onclick="show_loader();"><b>nematode</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-phylogeny/" class="suggestion"onclick="show_loader();"><b>phylogeny</b></a><br/><a href="/q-humans/" class="suggestion"onclick="show_loader();"><b>humans</b></a><br/></div></div></div><div class="pagenav"><a href="/q-morphometrics/p-9/" rel="nofollow"><b>previous</b></a> <a href="/q-morphometrics/p-8/" rel="nofollow">8</a> <a href="/q-morphometrics/p-9/" rel="nofollow">9</a> <b>10</b> <a href="/q-morphometrics/p-11/" rel="nofollow">11</a> <a href="/q-morphometrics/p-12/" rel="nofollow">12</a> <a href="/q-morphometrics/p-11/" id="next" rel="nofollow"><b>next</b></a> </div><br></div>
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