Results 201 to 210 of about 14,861 (265)

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Tramadol modulates Lucilia sericata development: clinical larval therapy and forensic insights. [PDF]

Sci Rep
Hodecek J, Portevin D, Luedin S, Pflueger V, Vogel G, Varlet V.   +5 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Effects of increasing narasin doses on feedlot performance, feeding behavior, carcass traits, and rumen-cecum morphometrics in Nellore cattle. [PDF]

PLoS One
Ferreira da Silva LA, Casali DM, Lélis ALJ, Leiva T, Rodrigues MC, Barroso JPR, Lasmar PVF, Araújo GLO, Virgínio Júnior GF, de Souza JM, Millen DD.   +10 more
europepmc   +1 more source

Low‐Field MRI as a Multiparametric Tool for Large Engineered Tissue Characterization

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Advances in 3D bioprinting have enabled the fabrication of large and complex engineered tissues, but their increasing size demands non‐invasive tools for monitoring structure, maturation, and perfusion. Magnetic Resonance Imaging (MRI) offers unique multiparametric capabilities, yet high‐field systems remain costly and inaccessible for most ...
Yilbert Gimenez, Valernst Martial Gilmus, Elliott Cowles, Lucie Essayan, Vincent Semet, Michel Cabrera, Christophe A. Marquette, Simon A. Lambert, Emma Petiot   +8 more
wiley   +1 more source

Anteroposterior suprasellar diameter as a predictor of gross total resection in pituitary adenomas with suprasellar extension: A retrospective cohort study. [PDF]

Surg Neurol Int
García Martínez JA, Soto Polendo ÁA, Candelas Rangel JA, Reyes Soto G, Castillo Rangel C, Cherubin T, Peralta Baez IA, Encarnacion Ramírez MJ.   +7 more
europepmc   +1 more source

Beyond wound sealing: A dual‐functional adhesive nanofiber membrane promoting coagulation and osteogenesis in extraction sites

BMEMat, EarlyView.
Inspired by the suction mechanics of octopus suckers, a dual‐layer nanofiber membrane integrates antibacterial protection, strong wet adhesion, and osteogenic support, offering a bioinspired strategy for effective hemostasis and alveolar bone preservation.
Huijing Ma, Liheng Gao, Hao Liang, Wentao Jiang, Junyi Wang, Jiajia Wang, Shuhan Duan, Lingxi Meng, Adilijiang Yimiti, Wenjie Zhang   +9 more
wiley   +1 more source

Otolith Morphological Characteristics of Major Schizothoracinae Fish Species in Tibet and Genus-Level Morphological Discrimination. [PDF]

Animals (Basel)
Wang Y, Zhou Y, Qiao L, Zhang H, Long L, Su J, Zhou C, Han Z, Liu H.   +8 more
europepmc   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Wnt5a gain- and loss-of-function in bone have distinct craniofacial phenotypes. [PDF]

JBMR Plus
Houchen CJ, Hahn Leat P, Delich C, Vang J, Yingling-Haggard S, Roberts JL, Drissi H, Bumann EE.   +7 more
europepmc   +1 more source