Results 91 to 100 of about 452,856 (299)

Initial Metabolic Profiles Are Associated with 7-Day Survival among Infants Born at 22-25 Weeks of Gestation. [PDF]

, 2018
OBJECTIVE:To evaluate the association between early metabolic profiles combined with infant characteristics and survival past 7 days of age in infants born at 22-25 weeks of gestation. STUDY DESIGN:This nested case-control consisted of 465 singleton live
Anderson, James G, Baer, Rebecca J, Jelliffe-Pawlowski, Laura L, Oltman, Scott P, Pantell, Matthew S, Partridge, J Colin, Rand, Larry, Rogers, Elizabeth E, Ryckman, Kelli K, Steurer, Martina A   +9 more
core   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

Associations of cardiovascular–kidney–metabolic syndrome stages with premature mortality and the role of social determinants of health

The Journal of Nutrition, Health and Aging
Objectives: The American Heart Association defined cardiovascular–kidney–metabolic (CKM) syndrome as a novel multi-stage disorder. We examined the associations of CKM stages with premature mortality and the role of social determinants of health (SDOHs ...
Ruixin Zhu, Ran Wang, Jingjing He, Langrun Wang, Huiyu Chen, Yifan Wang, Peng An, Keji Li, Fazheng Ren, Weili Xu, J. Alfredo Martinez, Anne Raben, Jie Guo   +12 more
doaj   +1 more source

Targeting Chronically Homeless Veterans with HUD-VASH [PDF]

, 2009
Hundreds of veterans are sleeping on the street or in the emergency shelter system in the District of Columbia. This brief examines data from the vulnerability index survey, completed by the DC Department of Health and Human Services and Common Ground, a
Mary Cunningham
core   +1 more source

Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial. [PDF]

, 2020
BackgroundNitric oxide (NO) plays an important role in normal postnatal transition. Our aims were to determine whether adding inhaled NO (iNO) decreases supplemental oxygen exposure in preterm infants requiring positive pressure ventilation (PPV) during ...
Anderson, Michael, Dannaway, Douglas, Helmbrecht, Ashley, Lakshminrusimha, Satyan, Manfredo, Amy, McCoy, Michael, Noori, Shahab, Riley, Julee, Sekar, Krishnamurthy, Szyld, Edgardo, Wlodaver, Anne   +10 more
core  

Comparing early years and childhood experiences and outcomes in Scotland, England and three city-regions: a plausible explanation for Scottish ‘excess’ mortality? [PDF]

, 2014
Background Negative early years and childhood experiences (EYCE), including socio-economic circumstances, parental health and parenting style, are associated with poor health outcomes both in childhood and adulthood.
O’Dowd, John, Taulbut, Martin, Walsh, David   +2 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

The Effect of Kangaroo Mother Care Method Toward Weight Gain and Length of Stay Among Low Birth Weight Baby [PDF]

, 2018
Infant mortality needs to get serious attention. Special efforts are relatively easy and inexpensive in the handling and care is through treatment methods can improve the stability ofKangaroo Mother Care(KMC) for babies and breastfeeding.The effort ...
Lisnawati, L. (Lisnawati), Muliani, M. (Muliani)   +1 more
core   +2 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source