Results 51 to 60 of about 2,729,591 (295)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Effects of vitamin D3 injection in close‐up period on insulin resistance and energy balance in transition dairy cows

Veterinary Medicine and Science, 2022
Background Many studies in dairy cows are towards calcium homeostasis and there is a lack of knowledge about the effect of vitamin D in preventing insulin resistance and improving energy balance in the transition period of dairy cows.
Morteza Hassanabadi, Mehrdad Mohri, Hesam. A. Seifi   +2 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Does early childhood adversities affect physical, cognitive and language development in indian children? Evidence from a panel study

SSM: Population Health, 2020
Early childhood adversities are known to impair the development potential of children, however, there is limited evidence for the same in the Indian context. This study provides evidence of the effect of relevant biological and social risk factors during
Ronak Paul, Abhishek Singh
doaj  

Trends in road transport collision deaths in the Irish paediatric population: a retrospective review of mortality data, 1991–2015

BMJ Paediatrics Open, 2019
Objective To establish the incidence of road transport collision (RTC) fatalities in the Irish paediatric population, examining trends in fatality rates over a period of 25 years, during which several national road safety interventions were implemented ...
Cliona McGarvey, Karina Hamilton, Jean Donnelly, Alf J Nicholson   +3 more
doaj   +1 more source

Heterogeneity in subnational mortality in the context of the COVID-19 pandemic: the case of Belgian districts in 2020

Archives of Public Health, 2022
Background The COVID-19 pandemic has led to major shocks in mortality trends in many countries. Yet few studies have evaluated the heterogeneity of the mortality shocks at the sub-national level, rigorously accounting for the different sources of ...
Benjamin-Samuel Schlüter, Bruno Masquelier, Carlo Giovanni Camarda   +2 more
doaj   +1 more source

THE MORTALITY OF APPENDICITIS. [PDF]

JAMA: The Journal of the American Medical Association, 1901
During the year 1900 there were operated upon at the German Hospital, Philadelphia, 268 cases of appendicitis, of which number 144 were acute attacks of the disease and 124 were chronic. Of those operated upon during the acute stage of the disease, 26, or 17.8 per cent., died, either from the disease or from some intercurrent trouble arising during the
George G. Ross, John B. Deaver
openaire   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Racial disparities in mortality in the adult hispanic population

SSM: Population Health, 2020
Objective: We addressed three research questions: (1) Are there racial mortality disparities in the adult Hispanic population that resemble those observed in the non-Hispanic population in the US? (2) Does nativity mediate the race-mortality relationship
Elizabeth Arias, Norman J. Johnson, Betzaida Tejada Vera   +2 more
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source