Results 71 to 80 of about 5,935,465 (357)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Association of precalving serum NEFA concentrations with postpartum diseases and reproductive performance in multiparous Holstein cows: Cut‐off values

open access: yesVeterinary Medicine and Science, 2023
Background High concentrations of NEFA relative to a defined reference or ‘cut‐point’ values before calving can predict the risk of specific or collective periparturient disease events.
Samuel Kia, Mehrdad Mohri, Hesam A Seifi
doaj   +1 more source

Variations in amenable mortality--trends in 16 high-income nations.

open access: yes, 2011
BACKGROUND: There has been growing interest in the comparison of health system performance within and between countries, using a range of different indicators. This study examines trends in amenable mortality, as one measure of health system performance,
McKee, Martin, Nolte, Ellen
core   +1 more source

How small is too small? A systematic review of center volume and outcome after cardiac transplantation [PDF]

open access: yes, 2012
Background—The aim of this study was to assess the relationship between the volume of cardiac transplantation procedures performed in a center and the outcome after cardiac transplantation.
Gardner, R.S.   +6 more
core   +2 more sources

Size-related Hooking Mortality of Incidentally Caught Chinook Salmon, Oncorhynchus tshawytscha [PDF]

open access: yes, 1989
Mortality associated with the incidental catch and release by commercial trollers of two size classes of chinook salmon, Oncorhynchus tshawytscha, was assessed. Observed cumulative mortality 4-6 days after hooking was 18.3 percent for sublegal-sizefish «
Celewycz, Adrian   +3 more
core  

Low molecular weight Adiponectin increases the mortality risk in very old patients [PDF]

open access: yes, 2018
Despite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been frequently reported as an independent positive predictor of cardiovascular mortality.
Canale, Maria Paola   +7 more
core   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Socioeconomic inequalities in tobacco cessation among Indians above 15 years of age from 2009 to 2017: evidence from the Global Adult Tobacco Survey (GATS)

open access: yesBMC Public Health, 2022
Background Tobacco is strongly associated with socioeconomic status (SES), however evidence on differences in tobacco cessation by socio-economic attributes remains fragmented, especially in developing countries.
Rufi Shaikh, Nandita Saikia
doaj   +1 more source

Black mortality in antebellum Savannah [PDF]

open access: yes, 2013
Black mortality in an urban environment in the antebellum South is relatively under-researched. This article is based on burial records from Savannah between 1853 and 1861 and argues that black mortality in Savannah was noticeably better than on nearby ...
Lockley, Timothy James
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

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