Results 81 to 90 of about 3,667,281 (314)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Levels and trends in child mortality

, 2010
The United Nations Inter-agency Group for Child Mortality Estimation (UN-IGME) updates child mortality estimates annually for monitoring progress. This report presents the UN-IGME's latest estimates of under-five, infant and neonatal mortality and ...
World Health Organization, World Bank Group, United Nations, UNICEF   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Preventing infant mortality in Ohio task force report.

, 2009
Title from PDF cover (viewed on May 25, 2010).; "November 2009."; Includes bibliographical references (p.

core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Preventing infant mortality in Ohio task force report : executive summary.

, 2009
Title from PDF cover (viewed on May 25, 2010).; "November 2009."; Harvested from the web on 5/25 ...

core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Causes of death among infants and children in the Child Health and Mortality Prevention Surveillance (CHAMPS) network

, 2023
Importance The number of deaths of children younger than 5 years has been steadily decreasing worldwide, from more than 17 million annual deaths in the 1970s to an estimated 5.3 million in 2019 (with 2.8 million deaths occurring in those aged 1-59 ...
Assefa, Nega, Dessie, Yadeta, Tippett Barr, Beth A, Madhi, Shabir A, Breiman, Robert F, Bassey, Ima-Abasi, Baillie, Vicky, Mandomando, Inacio, Child Health and Mortality Prevention Surveillance (CHAMPS) Netw, Mahtab, Sana, Gurley, Emily S, El Arifeen, Shams, Duran-Frigola, Miquel, Kaluma, Erick, Rahman, Afruna, Madewell, Zachary J, Akelo, Victor, Tapia, Milagritos D, Onyango, Dickens, Samura, Solomon, Ajanovic, Sara, Keita, Adama Mamby, Islam, Kazi Munisul, Bassat, Quique, Ogbuanu, Ikechukwu Udo, Kotloff, Karen L, Rogena, Emily, Madrid, Lola, Scott, J Anthony G, Mehta, Ashka, Onyango, Peter, Omore, Richard, Sitoe, Antonio, Tesfaye, Tseyon, Blau, Dianna M, Alam, Muntasir, Mutevedzi, Portia, Sow, Samba, Whitney, Cynthia G, Varo, Rosauro, Thwala, Bukiwe Nana   +40 more
core   +1 more source

ON THE MORTALITY AT GLASGOW, AND ON THE INCREASING MORTALITY IN ENGLAND. [PDF]

The Lancet
n ...
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source