Results 241 to 250 of about 369,180 (307)

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Tracking progress towards Sustainable Development Goal 3.2 in Kenya using time series models. [PDF]

BMJ Glob Health
Dlamini WJ, Melesse SF, Mwambi HG.
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Validation of a De Novo Health Economic Model for Finerenone in Heart Failure with Left Ventricular Ejection Fraction ≥40. [PDF]

J Mark Access Health Policy
Lemański T, Folkerts K, McEwan P, Mernagh P, Żemojdzin MR, Pochopień M.   +5 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Health impact of alcohol use in the USA: a protocol of a systematic review and modelling study. [PDF]

BMJ Open
Shield K, Keyes K, Martinez P, Milam AJ, Rehm J, George S, Naimi TS.   +6 more
europepmc   +1 more source

Bayesian functional models for population forecasting

, 2013
Bijak, Jakub, Raymer, James, Shang, Han Lin, Smith, Peter W.F., Wisniowski, Arkadiusz   +4 more
core  

Cost-effectiveness of microprocessor-controlled prosthetic knees in the Dutch healthcare system: The impact of study duration on outcomes. [PDF]

Can Prosthet Orthot J
Kuhlmann A, Kannenberg A.
europepmc   +1 more source

A proposed method for estimating habitat suitability of weed biological control agents with experimentally derived thermal injury and weather data. [PDF]

Environ Entomol
Knight IA, Bingham FE, Harlow MM, Huang AH, Bohaty C, Harms NE.   +5 more
europepmc   +1 more source

Health workforce planning methods in rural and remote primary care: a scoping review. [PDF]

Hum Resour Health
Argus G, Gavaghan B, Spinks J.
europepmc   +1 more source