Results 121 to 130 of about 62,949 (264)

Temperature-attributable mortality projections under scenarios of climate change for Oslo, Norway. [PDF]

BMC Public Health
Vázquez Fernández L, Diz-Lois Palomares A, Rao S, Vicedo-Cabrera AM.   +3 more
europepmc   +1 more source

What can we learn from indirect estimations on mortality in Mongolia, 1969-1989? [PDF]

The closure of Mongolia to international community during the 20th century resulted in a dearth of available data and analytic demographic studies. In the absence of mortality analysis during the socialist period, this paper proposes the use of indirect ...
Thomas Spoorenberg
core  

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Cancer mortality projections through 2026 among young adults in 15 upper-middle and high-income countries with focus on colorectal cancer. [PDF]

Cancer Causes Control
Mignozzi S, Santucci C, Alicandro G, Pizzato M, Jha P, Negri E, La Vecchia C.   +6 more
europepmc   +1 more source

The effects of war losses on mortality estimates for Italy [PDF]

For countries that experience substantial war losses in a given time period, the exclusion of military deaths can have an important impact on estimates of mortality and life expectancy. In this paper, we start by reviewing Vallin’s work in accounting for
Silvia Bruzzone, Graziella Caselli, Dana Glei   +2 more
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Global burden of tracheal, bronchus, and lung cancer attributable to second-hand smoke exposure from 1992 to 2021: an age-period-cohort analysis and 25-year mortality projections. [PDF]

Front Public Health
Lin HM, Lin B, Liao XP, Hong H, Cai XT, Zhuang XB.   +5 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Premature mortality projections to inform clinical practice and public health priorities. [PDF]

Lancet Reg Health West Pac
Islam SMS, Miranda JJ, Zoungas S, Maddison R.   +3 more
europepmc   +1 more source

Childhood Mortality and Economic Growth [PDF]

This paper investigates the extent to which the decline in childhood mortality over the last three decades can be attributed to economic growth. In doing this, it exploits the considerable variation in growth over this period, across states and over time.
Sonia Bhalotra
core