Results 161 to 170 of about 3,071,110 (344)

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

CHIMP: A SIMPLE POPULATION MODEL FOR USE IN INTEGRATED ASSESSMENT OF GLOBAL ENVIRONMENTAL CHANGE [PDF]

We present the Canberra-Hamburg Integrated Model for Population (CHIMP), a new global population model for long-term projections. Distinguishing features of this model, compared to other model for secular population projections, are that (a) mortality ...
Brian S. Fisher, Guy Jakeman, Hom M. Pant, Malte Schwoon, Richard S.J. Tol   +4 more
core  

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

Real-world analysis and future trends of parkinson's disease burden and all-cause mortality in Shanghai Pudong: a population-based study of 3.17 million people

BMC Public Health
Background To assess all-cause Parkinson's disease (PD)-related and PD-specific mortality trends and years of life lost (YLL) in Shanghai Pudong (3.17 million population) from 2005–2021, and project future burdens through 2035.
Zheng Luo, Jie Xue, Yan Zhang, Yichen Chen, Aiqing Fan, Ru Liu, Wenchang Jia, Xiaoling Wu, Qizhe Wang, Huihui Lv, Yong Bi, Xiaopan Li   +11 more
doaj   +1 more source

Improving consistency in estimating future health burdens from environmental risk factors: Case study for ambient air pollution

Environment International
Future changes in exposure to risk factors should impact mortality rates and population. However, studies commonly use mortality rates and population projections developed exogenously to the health impact assessment model used to quantify future health ...
Christopher S. Malley, Susan C. Anenberg, Drew T. Shindell   +2 more
doaj   +1 more source

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

Spatiotemporal patterns and future trends of global ischemic stroke burden

Frontiers in Neurology
BackgroundIschemic stroke remains a leading cause of morbidity and mortality worldwide, with substantial heterogeneity across regions, sexes, age groups, and levels of socioeconomic development.
Ruojing Zhang, Wenjun Chen, Mingjin Zhu, Yufei Xu   +3 more
doaj   +1 more source

A methodology for population projections: an application to Spain [PDF]

This paper looks at projections for the Spanish population by sex and age for the period of 2005 to 2050. These were carried out using forecasts for birth and mortality rates, and migration.
Andrés M. Alonso, Daniel Peña, Julio Rodríguez   +2 more
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Population ageing and immigration policy [PDF]

, 2004
In its simplest interpretation, population ageing is the increase in the average or median age of a population. It is the process by which there is a redistribution of relative population shares away from the younger to the older age ...
Wright, Robert E.
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