Results 191 to 200 of about 2,891,390 (297)

Projections of colorectal cancer mortality to 2040 in Mexico and their association with socioeconomic status. [PDF]

Cancer Causes Control
Arango CG, Noverón NR, Ceballos LFS, Islas EP, Guerrero FA, Navarro Ríos J.   +5 more
europepmc   +1 more source

DSG2+ Cancer Stem Cells Co‐Located With FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan, Le Tang, Tongji Xie, Mengwei Yang, Lin Li, Sheng Yang, Puyuan Xing, Xiaohong Han, Yuankai Shi   +8 more
wiley   +1 more source

Global, regional, and national burden of lower respiratory infections attributable to secondhand smoke exposure: Trends from 1990-2021 and projections to 2035. [PDF]

Chin Med J (Engl)
Zi G, Zhou L, Wang L, Zheng P, Liu X, Wei S.   +5 more
europepmc   +1 more source

Trends in Causes of Death in Low-Mortality Countries: Implications for Mortality Projections

, 2014
J. Bongaarts
semanticscholar   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Global Temporal Trends and Projections of Acute Hepatitis E Epidemiology for Adults 65 Years and Older from 1990 to 2021: Global Burden of Disease 2021 Based Study. [PDF]

Trop Med Infect Dis
Ma S, Wang Q, Lin J, Gao Y.
europepmc   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Comparative Modeling of Recent and Projected Trends in the Incidence and Mortality of Uterine Cancer. [PDF]

Obstet Gynecol
Rouse KJ, Hazelton WD, Frotscher A, Chen L, Prest MT, Ferris JS, Xu X, Melamed A, Hur C, Heckman-Stoddard BM, Samimi G, Bickell NA, Layne TM, Blank SV, Elkin EB, Myers ER, Havrilesky LJ, Kong CY, Wright JD.   +18 more
europepmc   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Divergent Trajectories and Risk Factor Attribution of Chronic Obstructive Pulmonary Disease Burden in China and the United States, 1990-2023: An Age-Period-Cohort Analysis with Projections to 2035 Based on the Global Burden of Disease Study 2023. [PDF]

Int J Chron Obstruct Pulmon Dis
Deng Y, Zhu Y, Chen C, Xu W, Yao W.
europepmc   +1 more source