Results 51 to 60 of about 3,086,327 (347)

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Pharmacotherapy prescribing pattern and outcome for hospitalized patients with severe and critical COVID-19

Current Issues in Pharmacy and Medical Sciences, 2022
There are many treatment modalities for COVID-19 – with varied outcome. Therefore, authors designed this study to assess prescribing patterns and the clinical outcome for hospitalized patients with severe and critical COVID-19 so as to determine the most
Assad Hayder
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Mortality trend due to traffic accident in young in the south of Brazil

Cadernos de Saúde Coletiva, 2018
Background Traffic accidents are a major global public health problem with an impact on morbidity and mortality. Objective The aim of this study was to analyze the mortality trend from road accidents among young adults.
Willian Augusto de Melo, Rosana Rosseto de Oliveira, Adriano Brischiliari, Sandra Marisa Pelloso, Maria Dalva de Barros Carvalho   +4 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Evaluation of biocidal activity of four Lamiaceae leaves on the black bean aphid Aphis fabae Scopoli, 1763 (Homoptera: Aphididae)

Acta Agriculturae Slovenica, 2022
The objective of our work was the valorisation of four aromatic plants growing spontaneously in Kabylia (Algeria) by the evaluation of their insecticidal activity against the black bean aphid Aphis fabae Scopoli, 1763.
Nadia BOUABIDA, Karima BENOUFELLA-KITOUS, Samia AIT AMAR, Ferroudja MEDJDOUB-BENSAAD, Farid GRAICHE   +4 more
doaj   +1 more source

The impact of the graduated driver licence scheme on road traffic accident youth mortality in New Zealand [PDF]

, 2008
This paper examines the impact of the introduction of New Zealand’s Graduated Driving Licence System (GDLS) on patterns of road traffic accident mortality amongst the young driving population from 1980 to 2001.
Dorling, D., Faulk, M., Kingham, S., Pearce, J.   +3 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Using HIV-attributable mortality to assess the impact of antiretroviral therapy on adult mortality in rural Tanzania. [PDF]

, 2014
BACKGROUND: The Tanzanian national HIV care and treatment programme has provided free antiretroviral therapy (ART) to HIV-positive persons since 2004.
Alison Wringe, Basia Zaba, Chifundo Kanjala, Clara Calvert, Denna Michael, Emma Slaymaker, Floyd S, Jim Todd, Kirkwood BR, Mark Urassa, Raphael Isingo, World Health Organization   +11 more
core   +1 more source